1. Panels
  2. Respiratory ciliopathies including non-CF bronchiectasis
  3. GAS8
STRs in panel
Prev Next
Regions in panel
Prev Next

Respiratory ciliopathies including non-CF bronchiectasis

Gene: GAS8

Green List (high evidence)
GAS8 (growth arrest specific 8)
EnsemblGeneIds (GRCh38): ENSG00000141013
EnsemblGeneIds (GRCh37): ENSG00000141013
OMIM: 605178, Gene2Phenotype
GAS8 is in 7 panels

4 reviews

Achchuthan Shanmugasundram (Genomics England Curator)

The 'new-gene-name' tag has been added as the official HGNC gene symbol for GAS8 is DRC4.
Created: 28 Apr 2025, 11:23 a.m. | Last Modified: 28 Apr 2025, 11:23 a.m.
Panel Version: 3.37
Created: 28 Apr 2025, 11:23 a.m.
Last Modified: 28 Apr 2025, 11:23 a.m.
Panel version: 3.37

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: GAS8; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD gene or intersection of >2 panels; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 1:54 p.m.
Created: 5 Dec 2018, 1:54 p.m.

Panel version: 0.2

Caroline Wright (Genomics England Curator)

Comment when marking as ready: Confirmed DD gene for PCD
Created: 10 May 2016, 9:38 a.m.
Comment on list classification: REF 26387594: Genome-wide exome sequence analyses identified recessive loss-of-function mutations in GAS8 encoding DRC4 in three independent PCD-affected families.
Created: 10 May 2016, 9:36 a.m.
Created: 10 May 2016, 9:36 a.m.

Panel version: Imported from Primary ciliary disorders panel version 0.20

Hannah Mitchison (UCL and GOSH)

Green List (high evidence)

None found yet
Created: 8 Dec 2015, 4:25 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Too new - not yet linked to the PCD mutations publication

Publications

Created: 8 Dec 2015, 4:25 p.m.

Panel version: Imported from Primary ciliary disorders panel version 0

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
Tags
new-gene-name
OMIM
605178
Clinvar variants
Variants in GAS8
Penetrance
None
Panels with this gene

History Filter Activity

28 Apr 2025, Gel status: 3

Added Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag new-gene-name tag was added to gene: GAS8.

17 Jan 2019, Gel status: 4

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene GAS8 was changed from to BIALLELIC, autosomal or pseudoautosomal

5 Dec 2018, Gel status: 3

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Green was added to GAS8. Rating Changed from Red List (low evidence) to Green List (high evidence)

5 Dec 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: GAS8 was added gene: GAS8 was added to Respiratory ciliopathies including non-CF bronchiectasis. Sources: NHS GMS Mode of inheritance for gene: GAS8 was set to