Respiratory ciliopathies including non-CF bronchiectasis
Gene: TTC25

TTC25 (tetratricopeptide repeat domain 25)
EnsemblGeneIds (GRCh38): ENSG00000204815
EnsemblGeneIds (GRCh37): ENSG00000204815
OMIM: 617095, Gene2Phenotype
TTC25 is in 4 panels

3 reviews

Catherine Snow (Genomics England)

Added new-gene-name tag, new approved HGNC gene symbol for TTC25 is ODAD4
Created: 24 Feb 2021, 5:11 p.m. | Last Modified: 24 Feb 2021, 5:11 p.m.

Panel Version: 1.43

Created: 24 Feb 2021, 5:11 p.m.
Last Modified: 24 Feb 2021, 5:11 p.m.
Panel version: 1.43

Matthew Edwards (Clinical Genetics & Genomics Lab, Royal Brompton & Harefield NHS Trust)

Green List (high evidence)

On Royal Brompton diagnostic panel, although no pathogenic variants found as yet. Gene codes for ODA complex protein and Wallmeier et al 2016 paper is very good evidence for rare cause of PCD.
Created: 21 Aug 2019, 7:01 p.m. | Last Modified: 21 Aug 2019, 7:01 p.m.

Panel Version: 0.150

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 35

Publications

27486780

Variants in this GENE are reported as part of current diagnostic practice

Created: 21 Aug 2019, 7:01 p.m.
Last Modified: 21 Aug 2019, 7:01 p.m.
Panel version: 0.150

Louise Daugherty (Genomics England Curator)

Green List (high evidence)

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: TTC25; Suggested initial gene rating: Green; Evidence for inclusion: OMIM PCD gene or intersection of >2 panels; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 5 Dec 2018, 1:54 p.m.

Created: 5 Dec 2018, 1:54 p.m.

Panel version: 0.2

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Green
NHS GMS

Phenotypes

Ciliary dyskinesia, primary, 35, OMIM:617092

Tags

new-gene-name

OMIM

617095

Clinvar variants

Variants in TTC25

Penetrance

None

Publications

Panels with this gene

History Filter Activity

13 Jul 2022, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: TTC25 were changed from Ciliary dyskinesia, primary 35, 617092 to Ciliary dyskinesia, primary, 35, OMIM:617092

13 Jul 2022, Gel status: 3

Set publications

Arina Puzriakova (Genomics England Curator)

Publications for gene: TTC25 were set to 27486780

24 Feb 2021, Gel status: 3

Added Tag

Catherine Snow (Genomics England)

Tag new-gene-name tag was added to gene: TTC25.

4 Sep 2019, Gel status: 3