1. Panels
  2. Multiple monogenic benign skin tumours
  3. TMC6
STRs in panel
Prev Next
Regions in panel
Prev Next

Multiple monogenic benign skin tumours

Gene: TMC6

No list
TMC6 (transmembrane channel like 6)
EnsemblGeneIds (GRCh38): ENSG00000141524
EnsemblGeneIds (GRCh37): ENSG00000141524
OMIM: 605828, Gene2Phenotype
TMC6 is in 5 panels

1 review

Rebecca Foulger (Genomics England curator)

Red List (low evidence)

This gene was demoted from Green to Grey as the gene is not present on the shorter revised list subsequently submitted by Thomas Cullup and Veronica Kinsler (London North GLH) on 18.Feb.2019 to more accurately match Clinical Indication R230.
Created: 19 Feb 2019, 7:43 p.m.
This gene was part of an initial gene list collated by Thomas Cullup, GOSH and Veronica Kinsler, UCL, 25.Jan.2019 on behalf of the GMS Skin Specialist Test Group. Gene Symbol submitted: TMC6; Suggested initial gene rating: Green; Evidence for inclusion: none provided; Evidence for exclusion: none provided; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none provided.
Created: 29 Jan 2019, 10:38 a.m.
Created: 29 Jan 2019, 10:38 a.m.

Panel version: 0.7

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • London North GLH
  • NHS GMS
Phenotypes
  • Epidermodysplasia verruciformis, 226400
  • Epidermodysplasia verruciformis
Tags
curated_removed
OMIM
605828
Clinvar variants
Variants in TMC6
Penetrance
None
Panels with this gene

History Filter Activity

26 Feb 2021, Gel status: 0

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag curated_removed tag was added to gene: TMC6.

19 Feb 2019, Gel status: 0

Added New Source, Status Update

Rebecca Foulger (Genomics England curator)

Source Expert Review Removed was added to TMC6. Rating Changed from Green List (high evidence) to No List (delete)

18 Feb 2019, Gel status: 4

Added New Source

Rebecca Foulger (Genomics England curator)

Source London North GLH was added to TMC6.

29 Jan 2019, Gel status: 4

Set Phenotypes

Rebecca Foulger (Genomics England curator)

Added phenotypes Epidermodysplasia verruciformis, 226400 for gene: TMC6

29 Jan 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: TMC6 was added gene: TMC6 was added to Multiple monogenic benign skin tumours. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: TMC6 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: TMC6 were set to Epidermodysplasia verruciformis