GMS Respiratory specialist test group Laterality disorders and isomerism
Gene: LZTFL1

LZTFL1 (leucine zipper transcription factor like 1)
EnsemblGeneIds (GRCh38): ENSG00000163818
EnsemblGeneIds (GRCh37): ENSG00000163818
OMIM: 606568, Gene2Phenotype
LZTFL1 is in 16 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list and info collated by Ian Berry Leeds Genetics Laboratory November 2018 on behalf of the GMS Respiratory specialist test group. Gene Symbol submitted: LZTFL1; Suggested intial gene rating: Amber; Evidence for inclusion: BBS17 in OMIM; rare reports of dextrocardia; Evidence for exclusion: Laterality abnormalities seen in <2% of BBS patients (CRIBBS), disorder is syndromic and otherwise recognisable; polydactyly/delay more prominent early features.; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given
Created: 26 Nov 2018, 2:25 p.m.

Created: 26 Nov 2018, 2:25 p.m.

Panel version: 0.1

Details

Sources

Expert Review Amber
NHS GMS

OMIM

606568

Clinvar variants

Variants in LZTFL1

Penetrance

None

Panels with this gene

History Filter Activity

26 Nov 2018, Gel status: 2

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Amber was added to LZTFL1. Rating Changed from Red List (low evidence) to Amber List (moderate evidence)

26 Nov 2018, Gel status: 1

Created, Added New Source, Set mode of inheritance