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  2. GMS Musculoskeletal specialist test group Skeletal dysplasia
  3. WISP3
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GMS Musculoskeletal specialist test group Skeletal dysplasia

Gene: WISP3

Green List (high evidence)
WISP3 (WNT1 inducible signaling pathway protein 3)
EnsemblGeneIds (GRCh38): ENSG00000112761
EnsemblGeneIds (GRCh37): ENSG00000112761
OMIM: 603400, Gene2Phenotype
WISP3 is in 2 panels

2 reviews

Louise Daugherty (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol for WISP3 is CCN6
Created: 9 May 2019, 4:20 p.m.
Created: 9 May 2019, 4:20 p.m.

Panel version: 0.31

Tracy Lester (Genetics laboratory, Oxford UK)

Green List (high evidence)

Genetic inflammatory/rheumatoid-like osteoarthropathies gp of SD, green - many recessive variants identified; Review on behalf of Tracy Lester/Michael Oldridge
Created: 6 Mar 2019, 11:52 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Arthropathy, progressive pseudorheumatoid, of childhood 208230; Spondyloepiphyseal dysplasia tarda with progressive arthropathy 208230

Created: 6 Mar 2019, 11:52 a.m.

Panel version: 0.2

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Arthropathy, progressive pseudorheumatoid, of childhood 208230
  • Spondyloepiphyseal dysplasia tarda with progressive arthropathy 208230
Tags
new-gene-name
OMIM
603400
Clinvar variants
Variants in WISP3
Penetrance
None
Panels with this gene

History Filter Activity

9 May 2019, Gel status: 4

Added Tag

Louise Daugherty (Genomics England Curator)

Tag new-gene-name tag was added to gene: WISP3.

6 Mar 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Eleanor Williams (Genomics England Curator)

gene: WISP3 was added gene: WISP3 was added to GMS Musculoskeletal specialist test group Skeletal dysplasia. Sources: NHS GMS,Expert Review Green Mode of inheritance for gene: WISP3 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WISP3 were set to Arthropathy, progressive pseudorheumatoid, of childhood 208230; Spondyloepiphyseal dysplasia tarda with progressive arthropathy 208230