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Childhood onset hereditary spastic paraplegia v3.9 AIMP1 Mafalda Gomes Tag Q3_21_MOI was removed from gene: AIMP1.
Childhood onset hereditary spastic paraplegia v3.9 AIMP1 Mafalda Gomes commented on gene: AIMP1
Childhood onset hereditary spastic paraplegia v3.8 AIMP1 Mafalda Gomes Mode of inheritance for gene AIMP1 was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to BIALLELIC, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia v2.51 AIMP1 Arina Puzriakova Tag Q3_21_MOI tag was added to gene: AIMP1.
Childhood onset hereditary spastic paraplegia v2.51 AIMP1 Arina Puzriakova Added comment: Comment on mode of inheritance: MOI should be updated from 'both mono- and biallelic' to 'biallelic' only at the next GMS panel update (tagged Q3_21_MOI).

Literature review showed that all affected individuals harbour biallelic variants, while heterozygous variant carriers are asymptomatic. The MOI is also biallelic in OMIM, Gen2Phen, and all other relevant panels.
Childhood onset hereditary spastic paraplegia v2.51 AIMP1 Arina Puzriakova Mode of inheritance for gene: AIMP1 was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia v2.50 AIMP1 Arina Puzriakova Phenotypes for gene: AIMP1 were changed from Leukodystrophy, hypomyelinating, 3, 260600 to Leukodystrophy, hypomyelinating, 3, OMIM:260600
Childhood onset hereditary spastic paraplegia v1.161 AIMP1 Louise Daugherty Mode of inheritance for gene: AIMP1 was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia v1.160 AIMP1 Louise Daugherty Publications for gene: AIMP1 were set to 21092922
Childhood onset hereditary spastic paraplegia v1.159 AIMP1 Louise Daugherty Deleted their comment
Childhood onset hereditary spastic paraplegia v1.75 AIMP1 Louise Daugherty Source Yorkshire and North East GLH was added to AIMP1.
Childhood onset hereditary spastic paraplegia v1.74 AIMP1 Louise Daugherty commented on gene: AIMP1: Rating and review submitted on behalf of James Polke (Neurogenetics Laboratory,Institute of Neurology, London), on behalf of London North GLH for GMS Neurology specialist test group.
Childhood onset hereditary spastic paraplegia v1.73 AIMP1 Nick Beauchamp reviewed gene: AIMP1: Rating: GREEN; Mode of pathogenicity: None; Publications: 21092922, 30477741, 30486714; Phenotypes: ; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia v1.48 AIMP1 Louise Daugherty reviewed gene: AIMP1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Childhood onset hereditary spastic paraplegia v1.6 AIMP1 James Polke reviewed gene: AIMP1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: Leukodystrophy, hypomyelinating, 3, autosomomal recessive, 260600; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia v1.5 AIMP1 Louise Daugherty Source NHS GMS was added to AIMP1.
Childhood onset hereditary spastic paraplegia v1.4 AIMP1 Louise Daugherty Source London North GLH was added to AIMP1.
Childhood onset hereditary spastic paraplegia v1.3 AIMP1 Louise Daugherty Added phenotypes Leukodystrophy, hypomyelinating, 3, 260600 for gene: AIMP1
Childhood onset hereditary spastic paraplegia v0.64 AIMP1 Louise Daugherty Phenotypes for gene: AIMP1 were changed from 260600 to Leukodystrophy, hypomyelinating, 3, 260600
Childhood onset hereditary spastic paraplegia v0.62 AIMP1 Arianna Tucci commented on gene: AIMP1
Childhood onset hereditary spastic paraplegia v0.6 AIMP1 Sarah Leigh gene: AIMP1 was added
gene: AIMP1 was added to Hereditary spastic paraplegia - childhood onset. Sources: Expert list,Expert Review Green
Mode of inheritance for gene: AIMP1 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: AIMP1 were set to 21092922
Phenotypes for gene: AIMP1 were set to 260600