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Hereditary neuropathy or pain disorder v6.148 ASAH1 Sarah Leigh Tag Q3_24_promote_green was removed from gene: ASAH1.
Tag Q3_24_NHS_review was removed from gene: ASAH1.
Hereditary neuropathy or pain disorder v6.148 ASAH1 Sarah Leigh commented on gene: ASAH1: The rating of this gene has been updated to green following NHS Genomic Medicine Service approval.
Hereditary neuropathy or pain disorder v6.147 ASAH1 Sarah Leigh Source NHS GMS was added to ASAH1.
Source Expert Review Green was added to ASAH1.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Hereditary neuropathy or pain disorder v6.28 ASAH1 Sarah Leigh Phenotypes for gene: ASAH1 were changed from Progressive myoclonic epilepsy; motor neuropathy to spinal muscular atrophy-progressive myoclonic epilepsy syndrome, MONDO:0008045; Spinal muscular atrophy with progressive myoclonic epilepsy, OMIM:159950
Hereditary neuropathy or pain disorder v6.25 ASAH1 Sarah Leigh Classified gene: ASAH1 as Amber List (moderate evidence)
Hereditary neuropathy or pain disorder v6.25 ASAH1 Sarah Leigh Gene: asah1 has been classified as Amber List (Moderate Evidence).
Hereditary neuropathy or pain disorder v6.24 ASAH1 Sarah Leigh Tag Q3_24_promote_green tag was added to gene: ASAH1.
Tag Q3_24_NHS_review tag was added to gene: ASAH1.
Hereditary neuropathy or pain disorder v6.20 ASAH1 Sarah Leigh reviewed gene: ASAH1: Rating: GREEN; Mode of pathogenicity: ; Publications: 534421, 22703880; Phenotypes: spinal muscular atrophy-progressive myoclonic epilepsy syndrome, MONDO:0008045, Spinal muscular atrophy with progressive myoclonic epilepsy, OMIM:159950; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder v5.19 ASAH1 Alexander Rossor gene: ASAH1 was added
gene: ASAH1 was added to Hereditary neuropathy or pain disorder. Sources: Expert list
Mode of inheritance for gene: ASAH1 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: ASAH1 were set to 24164096: 12571787: 534421: 22703880
Phenotypes for gene: ASAH1 were set to Progressive myoclonic epilepsy; motor neuropathy
Penetrance for gene: ASAH1 were set to Complete
Review for gene: ASAH1 was set to GREEN
Added comment: multiple affected individuals with peripheral neuropathy
Sources: Expert list