Activity
| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
8 actions
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.9 | ATM |
Achchuthan Shanmugasundram Tag Q2_24_promote_green was removed from gene: ATM. Tag Q2_24_MOI was removed from gene: ATM. Tag Q2_24_NHS_review was removed from gene: ATM. |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.9 | ATM | Achchuthan Shanmugasundram reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.8 | ATM |
Achchuthan Shanmugasundram Source NHS GMS was added to ATM. Source Expert Review Green was added to ATM. Rating Changed from Amber List (moderate evidence) to Green List (high evidence) |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM |
Sarah Leigh Tag Q2_24_promote_green tag was added to gene: ATM. Tag Q2_24_MOI tag was added to gene: ATM. Tag Q2_24_NHS_review tag was added to gene: ATM. |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh Classified gene: ATM as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.4 | ATM | Sarah Leigh Gene: atm has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Inherited pancreatic cancer v2.3 | ATM |
Terri McVeigh gene: ATM was added gene: ATM was added to Inherited pancreatic cancer. Sources: Other Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ATM were set to 34529012; 33509806 Phenotypes for gene: ATM were set to Breast, prostate, pancreatic cancer predisposition; recessive trait for ataxia telangiectasia Penetrance for gene: ATM were set to Incomplete Mode of pathogenicity for gene: ATM was set to Other Review for gene: ATM was set to GREEN Added comment: Discussed at UKCGG/Cancer Leads meeting 29th February 2024 - consensus that ATM should be added to this panel for diagnostic testing in individuals with pancreatic cancer fulfilling eligibility criteria. Reporting of variants should be restricted to truncating variants, high-risk missense c.7271T/G and exceptional variants as determined by Can-VIG UK, as per other panels where ATM is tested for cancer predisposition (R208/430) Sources: Other |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||