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Retinal disorders v6.8 ATXN7_CAG Sarah Leigh Classified STR: ATXN7_CAG as Green List (high evidence)
Retinal disorders v6.8 ATXN7_CAG Sarah Leigh Str: atxn7_cag has been classified as Green List (High Evidence).
Retinal disorders v6.7 ATXN7_CAG Sarah Leigh Tag Q2_24_promote_green was removed from STR: ATXN7_CAG.
Tag Q2_24_NHS_review was removed from STR: ATXN7_CAG.
Retinal disorders v6.7 ATXN7_CAG Sarah Leigh commented on STR: ATXN7_CAG: The rating of this STR has been updated to green following NHS Genomic Medicine Service approval.
Retinal disorders v5.15 ATXN7_CAG Sarah Leigh Tag STR tag was added to STR: ATXN7_CAG.
Tag Q2_24_promote_green tag was added to STR: ATXN7_CAG.
Tag Q2_24_NHS_review tag was added to STR: ATXN7_CAG.
Retinal disorders v5.15 ATXN7_CAG Sarah Leigh reviewed STR: ATXN7_CAG: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Retinal disorders v5.15 ATXN7_CAG Sarah Leigh Publications for STR: ATXN7_CAG were set to 27632585
Retinal disorders v5.14 ATXN7_CAG Sarah Leigh Classified STR: ATXN7_CAG as Amber List (moderate evidence)
Retinal disorders v5.14 ATXN7_CAG Sarah Leigh Str: atxn7_cag has been classified as Amber List (Moderate Evidence).
Retinal disorders v5.13 ATXN7_CAG Sarah Leigh Phenotypes for STR: ATXN7_CAG were changed from Maculopaty; Cone-Rod Dystrophy to Spinocerebellar ataxia 7, OMIM:164500; autosomal dominant cerebellar ataxia type II, MONDO:0016163
Retinal disorders v5.12 ATXN7_CAG Sarah Leigh Publications for STR: ATXN7_CAG were set to PMID: 27632585,
Retinal disorders v4.71 ATXN7_CAG Siying Lin STR: ATXN7_CAG was added
STR: ATXN7_CAG was added to Retinal disorders. Sources: Literature
Mode of inheritance for STR: ATXN7_CAG was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for STR: ATXN7_CAG were set to PMID: 27632585,
Phenotypes for STR: ATXN7_CAG were set to Maculopaty; Cone-Rod Dystrophy
Review for STR: ATXN7_CAG was set to GREEN
Added comment: PMID: 27632585 (father of proband), this ARVO abstract ( https://iovs.arvojournals.org/article.aspx?articleid=2768575) and cases from our clinical cohort, demonstrate that affected individuals can present with a seemingly isolated maculopathy or cone-rod dystrophy that precedes the onset of neurological symptoms
Sources: Literature