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Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 BCL10 Arina Puzriakova Tag for-review was removed from gene: BCL10.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 BCL10 Arina Puzriakova commented on gene: BCL10: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.528 BCL10 Arina Puzriakova Source Expert Review Green was added to BCL10.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.367 BCL10 Arina Puzriakova Classified gene: BCL10 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.367 BCL10 Arina Puzriakova Added comment: Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.367 BCL10 Arina Puzriakova Gene: bcl10 has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.366 BCL10 Arina Puzriakova Tag for-review tag was added to gene: BCL10.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.209 BCL10 Eleanor Williams Source Other was added to BCL10.
Publications for gene BCL10 were updated from 32048120; 25365219; 32086639 to 32086639; 25365219; 32048120
Primary immunodeficiency or monogenic inflammatory bowel disease v2.208 BCL10 Eleanor Williams reviewed gene: BCL10: Rating: ; Mode of pathogenicity: ; Publications: 25365219; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.58 BCL10 Ivone Leong Classified gene: BCL10 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.58 BCL10 Ivone Leong Added comment: Comment on list classification: Based on recent expert reviews and evidence, it has been decided that there is now enough evidence to support a gene-disease association. Therefore, this gene has been promoted from Amber to Green.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.58 BCL10 Ivone Leong Gene: bcl10 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.46 BCL10 Zornitza Stark reviewed gene: BCL10: Rating: GREEN; Mode of pathogenicity: None; Publications: 25365219, 32008135, 11163238, 12910267; Phenotypes: Immunodeficiency 37, MIM# 616098; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease v2.45 BCL10 Sophie Hambleton edited their review of gene: BCL10: Added comment: Additional case report describes recurrent infections with same cellular and immunological phenotypes in a child with homozygous null mutation, hence upgrade from amber to green gene status; Changed rating: GREEN; Changed publications: 25365219, 32008135
Primary immunodeficiency or monogenic inflammatory bowel disease v2.34 BCL10 Louise Daugherty Source IUIS Classification December 2019 was added to BCL10.
Added phenotypes Recurrent bacterial and viral infections, candidiasis, gastroenteritis; Immunodeficiencies affecting cellular and humoral immunity for gene: BCL10
Publications for gene BCL10 were updated from 25365219 to 32048120; 25365219; 32086639
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty commented on gene: BCL10
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty marked gene: BCL10 as ready
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty classified BCL10 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty classified BCL10 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty classified BCL10 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Sophie Hambleton reviewed gene: BCL10
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty edited their review of BCL10
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty commented on BCL10
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty reviewed BCL10
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty Added gene to panel
Primary immunodeficiency or monogenic inflammatory bowel disease BCL10 Louise Daugherty Added gene to panel