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Limb disorders v6.3 COL5A1 Eleanor Williams commented on gene: COL5A1
Limb disorders v6.3 COL5A1 Eleanor Williams Tag curated_removed tag was added to gene: COL5A1.
Limb disorders v6.2 COL5A1 Tracy Lester gene: COL5A1 was added
gene: COL5A1 was added to Limb disorders. Sources: NHS GMS
Mode of inheritance for gene: COL5A1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: COL5A1 were set to 21611149; 20847697
Phenotypes for gene: COL5A1 were set to EDS
Penetrance for gene: COL5A1 were set to Complete
Review for gene: COL5A1 was set to GREEN
Added comment: I am not sure if the right panel to add this gene but it should be included in R27 due to severe EDS presenting in childhood - this also applies to COL5A2. We have reported a possible fetal case of EDS with multiple joint flexions on scan and a nonsense variant in COL5A1
Sources: NHS GMS