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Dilated Cardiomyopathy and conduction defects v1.96 EYA4 Arina Puzriakova Classified gene: EYA4 as Red List (low evidence)
Dilated Cardiomyopathy and conduction defects v1.96 EYA4 Arina Puzriakova Added comment: Comment on list classification: Demoting from Green to Red - only single report of a case of DCM preceded by sensorineural hearing loss (possibly) associated with a deletion in EYA4 (PMID: 10769282). No other evidence of link with DCM, only definitive association is with non-syndromic hearing loss. Association is classified as provisional in OMIM and limited in ClinGen.
Dilated Cardiomyopathy and conduction defects v1.96 EYA4 Arina Puzriakova Gene: eya4 has been classified as Red List (Low Evidence).
Dilated Cardiomyopathy and conduction defects v1.95 EYA4 Arina Puzriakova Phenotypes for gene: EYA4 were changed from ?Cardiomyopathy, dilated, 1J (605362); Deafness, autosomal dominant 10 (601316); Cardiomyopathy, dilated, 1J to ?Cardiomyopathy, dilated, 1J, OMIM:605362
Dilated Cardiomyopathy and conduction defects v1.94 EYA4 Dmitrijs Rots reviewed gene: EYA4: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Dilated Cardiomyopathy and conduction defects v1.55 EYA4 Matthew Edwards reviewed gene: EYA4: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Dilated Cardiomyopathy and conduction defects v1.55 EYA4 Rebecca Whittington commented on gene: EYA4: ?Cardiomyopathy, dilated, 1J OMIM#605362; Deafness, autosomal dominant 10 OMIM#601316
Dilated Cardiomyopathy and conduction defects v1.54 EYA4 Rebecca Whittington commented on gene: EYA4: HGMD: 1 x variant assoc with DCM and deafness: Schonberger (2005) Nat Genet 37, 418. Included in review of DCM genes: Dalin 2017 International Journal of Cardiology 228 (2017) 742748, Hershberger 2013 Nat Rev Cardiol 10:531.
Dilated Cardiomyopathy and conduction defects v1.53 EYA4 Rebecca Whittington reviewed gene: EYA4: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Dilated Cardiomyopathy and conduction defects v1.47 EYA4 Ellen McDonagh Source South West GLH was added to EYA4.
Mode of inheritance for gene EYA4 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Dilated Cardiomyopathy and conduction defects v1.46 EYA4 Ellen McDonagh reviewed gene: EYA4: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Dilated Cardiomyopathy and conduction defects v1.45 EYA4 Ellen McDonagh Source London South GLH was added to EYA4.
Dilated Cardiomyopathy and conduction defects v1.44 EYA4 James Eden reviewed gene: EYA4: Rating: RED; Mode of pathogenicity: ; Publications: 15735644, 27532257; Phenotypes: ?Cardiomyopathy, dilated, 1J (605362), Deafness, autosomal dominant 10 (601316); Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown; Current diagnostic: yes
Dilated Cardiomyopathy and conduction defects v1.43 EYA4 Ellen McDonagh Source North West GLH was added to EYA4.
Added phenotypes ?Cardiomyopathy, dilated, 1J (605362); Deafness, autosomal dominant 10 (601316) for gene: EYA4
Publications for gene EYA4 were changed from to 27532257; 15735644
Dilated Cardiomyopathy and conduction defects v1.40 EYA4 Oxford Medical Genetics Laboratory edited their review of gene: EYA4: Added comment: Not fully reviewed however doesn't appear to be associated with primary non-syndromic teen/adult onset DCM.; Changed rating: RED
Dilated Cardiomyopathy and conduction defects v1.39 EYA4 Ellen McDonagh Source Wessex and West Midlands GLH was added to EYA4.
Rating Changed from Green List (high evidence) to Green List (high evidence)