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Paediatric disorders - additional genes v7.5 GPKOW Arina Puzriakova Classified gene: GPKOW as Amber List (moderate evidence)
Paediatric disorders - additional genes v7.5 GPKOW Arina Puzriakova Added comment: Comment on list classification: There is sufficient evidence to promote this gene to Green at the next GMS panel update - 3 unrelated cases with a multisystemic disorder due to hypomorphic or possible dominant-negative variants in this gene (PMID: 28612833; 40221893).
Paediatric disorders - additional genes v7.5 GPKOW Arina Puzriakova Gene: gpkow has been classified as Amber List (Moderate Evidence).
Paediatric disorders - additional genes v7.4 GPKOW Arina Puzriakova Tag Q2_25_ promote_green was removed from gene: GPKOW.
Tag Q3_25_promote_green tag was added to gene: GPKOW.
Paediatric disorders - additional genes v7.4 GPKOW Arina Puzriakova Entity copied from Fetal anomalies v6.12
Paediatric disorders - additional genes v7.4 GPKOW Arina Puzriakova gene: GPKOW was added
gene: GPKOW was added to Paediatric disorders - additional genes. Sources: Expert Review Amber,PAGE Additional Gene List
Q2_25_ promote_green tags were added to gene: GPKOW.
Mode of inheritance for gene: GPKOW was set to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Publications for gene: GPKOW were set to 28612833; 40221893
Phenotypes for gene: GPKOW were set to microcephaly with intrauterine growth restriction