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| Monogenic hearing loss v4.62 | FOXI1 |
Achchuthan Shanmugasundram changed review comment from: After NHS Genomic Medicine Service consideration, the mode of inheritance of this gene has not been changed and remains BIALLELIC, autosomal or pseudoautosomal. The review from North Thames GLH notes that no good recent evidence to support monoallelic/digenic inheritance and suggests keeping under review. The review from North West GLH notes that biallelic inheritance is only applicable to hearing loss in ClinGen / OMIM - fits with KCNJ10 and SLC26A4.; to: After NHS Genomic Medicine Service consideration, the mode of inheritance of this gene has not been changed and remains BIALLELIC, autosomal or pseudoautosomal. The review from North Thames GLH notes that no good recent evidence to support monoallelic/digenic inheritance and suggests keeping under review. The review from North West GLH notes that biallelic inheritance is only applicable to hearing loss in ClinGen / OMIM - fits with KCNJ10 and SLC26A4. |
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