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Intellectual disability v9.300 LAMC3 Arina Puzriakova Tag Q3_25_MOI was removed from gene: LAMC3.
Tag Q3_25_expert_review was removed from gene: LAMC3.
Tag Q3_25_demote_red was removed from gene: LAMC3.
Intellectual disability v9.299 LAMC3 Arina Puzriakova reviewed gene: LAMC3: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Intellectual disability v9.298 LAMC3 Arina Puzriakova Source NHS GMS was added to LAMC3.
Source Expert Review Red was added to LAMC3.
Mode of inheritance for gene LAMC3 was changed from BIALLELIC, autosomal or pseudoautosomal to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Rating Changed from Green List (high evidence) to Red List (low evidence)
Intellectual disability v9.146 LAMC3 Achchuthan Shanmugasundram Classified gene: LAMC3 as Green List (high evidence)
Intellectual disability v9.146 LAMC3 Achchuthan Shanmugasundram Added comment: Comment on list classification: The association of monoallelic variants with intellectual disability is disputed by the expert panel in ClinGen. There is no evidence of ID of moderate severity or worse in patients with biallelic variants. The patients only displayed developmental delay or mild ID. Hence, this gene should be demoted from green rating in the next GMS update.
Intellectual disability v9.146 LAMC3 Achchuthan Shanmugasundram Gene: lamc3 has been classified as Green List (High Evidence).
Intellectual disability v9.145 LAMC3 Achchuthan Shanmugasundram Tag Q3_25_MOI tag was added to gene: LAMC3.
Tag Q3_25_expert_review tag was added to gene: LAMC3.
Tag Q3_25_demote_red tag was added to gene: LAMC3.
Intellectual disability v9.145 LAMC3 Achchuthan Shanmugasundram edited their review of gene: LAMC3: Changed rating: RED; Changed mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Intellectual disability v9.145 LAMC3 Achchuthan Shanmugasundram edited their review of gene: LAMC3: Changed mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Intellectual disability v9.145 LAMC3 Achchuthan Shanmugasundram Publications for gene: LAMC3 were set to 21572413; 25529582; 24896178
Intellectual disability v9.144 LAMC3 Achchuthan Shanmugasundram reviewed gene: LAMC3: Rating: AMBER; Mode of pathogenicity: None; Publications: 21572413, 26802095, 29247375, 33639934, 34354730, 38758065; Phenotypes: Cortical malformations, occipital, OMIM:614115, occipital pachygyria and polymicrogyria, MONDO:0013583; Mode of inheritance: BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Intellectual disability v9.141 LAMC3 Eleanor Williams Publications for gene: LAMC3 were set to
Intellectual disability v9.140 LAMC3 Eleanor Williams Added comment: Comment on phenotypes: OMIM phenotype accessed on 21st October 2025
Intellectual disability v9.140 LAMC3 Eleanor Williams Phenotypes for gene: LAMC3 were changed from Cortical malformations, occipital, 614115; OCCIPITAL CORTICAL MALFORMATIONS to Cortical malformations, occipital, OMIM:614115; occipital pachygyria and polymicrogyria, MONDO:0013583
Intellectual disability v2.468 LAMC3 Louise Daugherty Source Victorian Clinical Genetics Services was added to LAMC3.
Intellectual disability LAMC3 BRIDGE consortium edited their review of LAMC3
Intellectual disability LAMC3 BRIDGE consortium edited their review of LAMC3
Intellectual disability LAMC3 BRIDGE consortium reviewed LAMC3