Activity
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7 actions
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| Severe early-onset obesity v5.10 | MC3R | Achchuthan Shanmugasundram Classified gene: MC3R as Red List (low evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v5.10 | MC3R | Achchuthan Shanmugasundram Gene: mc3r has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v5.9 | MC3R | Achchuthan Shanmugasundram Phenotypes for gene: MC3R were changed from obesity to {Obesity, severe, susceptibility to, BMIQ9}, OMIM:602025 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v5.8 | MC3R | Achchuthan Shanmugasundram Publications for gene: MC3R were set to PMID: 31090190 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v5.7 | MC3R | Achchuthan Shanmugasundram edited their review of gene: MC3R: Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v5.7 | MC3R | Achchuthan Shanmugasundram reviewed gene: MC3R: Rating: RED; Mode of pathogenicity: None; Publications: 31090190; Phenotypes: {Obesity, severe, susceptibility to, BMIQ9}, OMIM:602025; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Severe early-onset obesity v4.12 | MC3R |
Dmitrijs Rots gene: MC3R was added gene: MC3R was added to Severe early-onset obesity. Sources: Literature Mode of inheritance for gene: MC3R was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MC3R were set to PMID: 31090190 Phenotypes for gene: MC3R were set to obesity Penetrance for gene: MC3R were set to Incomplete Review for gene: MC3R was set to GREEN Added comment: PMID: 31090190 described a meta analysis of ~3k cases (including children) with obesity & ~2.5k controls and found a significant enrichment of LoF MC3R variants in obesity cases (OR = 3.07). Enough evidence for the green rating. Sources: Literature |
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