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Paroxysmal central nervous system disorders v0.159 MOG Rebecca Foulger Marked gene: MOG as ready
Paroxysmal central nervous system disorders v0.159 MOG Rebecca Foulger Gene: mog has been classified as Amber List (Moderate Evidence).
Paroxysmal central nervous system disorders v0.159 MOG Rebecca Foulger Classified gene: MOG as Amber List (moderate evidence)
Paroxysmal central nervous system disorders v0.159 MOG Rebecca Foulger Added comment: Comment on list classification: Kept rating as Amber based on consensus GLH review- insufficient evidence for Green rating.
Paroxysmal central nervous system disorders v0.159 MOG Rebecca Foulger Gene: mog has been classified as Amber List (Moderate Evidence).
Paroxysmal central nervous system disorders v0.158 MOG Rebecca Foulger commented on gene: MOG: Review and rating from Robyn Labrum (University College London Hospitals) was collated (September 30th 2019) on behalf of London North GLH for the GMS Neurology specialist test group for clinical indication R66: Paroxysmal central nervous system disorders. Suggested rating: None submitted but comment suggests Amber. This is a gene that was re-reviewed to reach a consensus, and therefore the rating by Robyn Labrum has changed from Green to Amber in PanelApp.
Paroxysmal central nervous system disorders v0.158 MOG Robyn Labrum edited their review of gene: MOG: Added comment: In a single large Spanish family across 4 generations. All 11 affected members studied and 1 who did not completely fulfill the diagnostic criteria for narcolepsy carried the mutation, whereas all 14 unaffected family members studied did not have the mutation. Is this sufficient evidence? If not then it should be amber.; Changed rating: AMBER
Paroxysmal central nervous system disorders v0.151 MOG Rebecca Foulger commented on gene: MOG: PMID:21907016: In affected members of a large Spanish family with narcolepsy and cataplexy, Hor et al. (2011) identified a heterozygous 398C-G transversion in the MOG gene (p.S133C). 12 family members had narcolepsy and cataplexy, 7 of whom were obese and 4 of whom had type 2 diabetes. All 11 affected members studied (plus 1 who did not completely fulfill the diagnostic criteria for narcolepsy) carried the variant, whereas all 14 unaffected family members studied did not have the variant.
Paroxysmal central nervous system disorders v0.136 MOG Rebecca Foulger Mode of inheritance for gene: MOG was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Paroxysmal central nervous system disorders v0.98 MOG Rebecca Foulger commented on gene: MOG: Review and rating from Robyn Labrum (University College London Hospitals) was collated (September 19th 2019) on behalf of London North GLH for the GMS Neurology specialist test group. Re-review of a subset of genes was conducted in September 2019 to reach a rating consensus for clinical indication R66: Paroxysmal central nervous system disorders. Suggested rating: Green.
Paroxysmal central nervous system disorders v0.97 MOG Robyn Labrum reviewed gene: MOG: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Paroxysmal central nervous system disorders v0.96 MOG Rebecca Foulger commented on gene: MOG: Review and rating from Penny Clouston (Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust) was collated (September 19th 2019) on behalf of West Midlands, Oxford and Wessex GLH for the GMS Neurology specialist test group. Re-review of a subset of genes was conducted in September 2019 to reach a rating consensus for clinical indication R66: Paroxysmal central nervous system disorders. A question mark was submitted for the rating because of a question over the level of evidence, therefore I uploaded an Amber review from Penny Clouston.
Paroxysmal central nervous system disorders v0.95 MOG Penny Clouston reviewed gene: MOG: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Paroxysmal central nervous system disorders v0.27 MOG Rebecca Foulger Source NHS GMS was added to MOG.
Paroxysmal central nervous system disorders v0.26 MOG Rebecca Foulger commented on gene: MOG: Review and rating from James Polke (Neurogenetics Laboratory, Institute of Neurology, London) was collated (February 2019) on behalf of London North GLH for the GMS Neurology specialist test group.
Paroxysmal central nervous system disorders v0.25 MOG James Polke reviewed gene: MOG: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Paroxysmal central nervous system disorders v0.24 MOG Rebecca Foulger Source London North GLH was added to MOG.
Paroxysmal central nervous system disorders v0.23 MOG Rebecca Foulger reviewed gene: MOG: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Paroxysmal central nervous system disorders v0.22 MOG Tracy Lester reviewed gene: MOG: Rating: AMBER; Mode of pathogenicity: ; Publications: 21907016; Phenotypes: Narcolepsy 7, 614250; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Paroxysmal central nervous system disorders v0.21 MOG Rebecca Foulger Source Wessex and West Midlands GLH was added to MOG.
Paroxysmal central nervous system disorders v0.3 MOG Ellen McDonagh Added phenotypes Narcolepsy 7, 614250 for gene: MOG
Paroxysmal central nervous system disorders v0.2 MOG Ellen McDonagh gene: MOG was added
gene: MOG was added to Paroxysmal neurological disorders, pain disorders and sleep disorders. Sources: Expert Review Amber
Mode of inheritance for gene: MOG was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: MOG were set to 21907016
Phenotypes for gene: MOG were set to Narcolepsy 7, 614250