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Early onset or syndromic epilepsy v8.18 MT-TK Arina Puzriakova Classified gene: MT-TK as Amber List (moderate evidence)
Early onset or syndromic epilepsy v8.18 MT-TK Arina Puzriakova Added comment: Comment on list classification: This gene should be promoted to Green at the next GMS panel update.
Early onset or syndromic epilepsy v8.18 MT-TK Arina Puzriakova Gene: mt-tk has been classified as Amber List (Moderate Evidence).
Early onset or syndromic epilepsy v8.17 MT-TK Arina Puzriakova Classified gene: MT-TK as Amber List (moderate evidence)
Early onset or syndromic epilepsy v8.17 MT-TK Arina Puzriakova Gene: mt-tk has been classified as Amber List (Moderate Evidence).
Early onset or syndromic epilepsy v8.16 MT-TK Arina Puzriakova gene: MT-TK was added
gene: MT-TK was added to Early onset or syndromic epilepsy. Sources: Literature
locus-type-rna-transfer, Q3_25_promote_green, Q3_25_NHS_review tags were added to gene: MT-TK.
Mode of inheritance for gene gene: MT-TK was set to MITOCHONDRIAL
Publications for gene: MT-TK were set to 1463006; 8228033; 18651333; 29663531; 33766967
Phenotypes for gene: MT-TK were set to MERRF syndrome, MONDO:0010790
Review for gene: MT-TK was set to GREEN
Added comment: Adding MT-TK to this panel by suggestion of North East and Yorkshire GLH where a patient was identified with a tier 3 diagnostic MT-TK variant due to absence of the gene on this applied panel.

MT-TK gene has been associated with severe mitochondrial diseases which includes myoclonic epilepsy - multiple (at least 8) unrelated cases with epilepsy as a presenting feature have been reported in the literature (PMID: 1463006; 8228033; 18651333; 29663531; 33766967)
Sources: Literature