Activity
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7 actions
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| Adult solid tumours cancer susceptibility v2.34 | MUTYH | Ida Ertmanska Tag Q4_25_expert_review tag was added to gene: MUTYH. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adult solid tumours cancer susceptibility v2.34 | MUTYH |
Ida Ertmanska Tag disputed tag was added to gene: MUTYH. Tag Q4_25_demote_red tag was added to gene: MUTYH. |
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| Adult solid tumours cancer susceptibility v2.34 | MUTYH |
Ida Ertmanska commented on gene: MUTYH: Comment on list classification: The gene-disease association between MUTYH and hereditary cancers has been disputed by the ClinGen Hereditary Cancer GCEP - classified as Disputed for familial ovarian cancer (AR & AD), Disputed for AR hereditary breast carcinoma and Refuted for AD hereditary breast carcinoma, and Disputed for colorectal cancer. MUTYH is linked to familial adenomatous polyposis 2 and classified as Definitive in ClinGen. More information: https://search.clinicalgenome.org/kb/genes/HGNC:7527 Based on the available evidence, MUTYH should be demoted to Red for Adult solid tumours cancer susceptibility at the next GMS panel update. |
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| Adult solid tumours cancer susceptibility v2.34 | MUTYH | Ida Ertmanska reviewed gene: MUTYH: Rating: RED; Mode of pathogenicity: None; Publications: 21063410, 24444654, 23946381, 29478780, 33309985, 33471991, 35172496; Phenotypes: Gastric cancer, somatic, OMIM:613659, Adenomas, multiple colorectal, OMIM:608456; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adult solid tumours cancer susceptibility v1.5 | MUTYH | Ivone Leong reviewed gene: MUTYH: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adult solid tumours cancer susceptibility v1.4 | MUTYH | Ivone Leong Source NHS GMS was added to MUTYH. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Adult solid tumours cancer susceptibility | MUTYH | Clare Turnbull reviewed MUTYH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||