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Primary immunodeficiency or monogenic inflammatory bowel disease v2.53 NFKBID Sarah Leigh Classified gene: NFKBID as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.53 NFKBID Sarah Leigh Added comment: Comment on list classification: Not associated with phenotype in OMIM or in Gen2Phen. The only variants are structural rearrangements that include NFKBID amongst other genes. PMID 26973645 reports "heterozygous mutation in the nfkbid gene encoding the atypical IκB protein IκBNS led to reduced steady state IgM and IgG3 antibody levels and impaired response to vaccination with TI-2 antigens in mice". Thus, variants in human NFKBID may also result in reduced levels of IgM and IgG3 and compromized vaccination responses.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.53 NFKBID Sarah Leigh Gene: nfkbid has been classified as Red List (Low Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.52 NFKBID Sarah Leigh Publications for gene: NFKBID were set to
Primary immunodeficiency or monogenic inflammatory bowel disease NFKBID Louise Daugherty marked gene: NFKBID as ready
Primary immunodeficiency or monogenic inflammatory bowel disease NFKBID Louise Daugherty classified NFKBID as Red List (low evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease NFKBID Sophie Hambleton reviewed gene: NFKBID
Primary immunodeficiency or monogenic inflammatory bowel disease NFKBID Louise Daugherty classified NFKBID as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease NFKBID Louise Daugherty Added gene to panel