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Hereditary neuropathy or pain disorder v6.164 NOTCH2NL Arina Puzriakova commented on gene: NOTCH2NL
Hereditary neuropathy or pain disorder v6.164 NOTCH2NL Arina Puzriakova Tag new-gene-name tag was added to gene: NOTCH2NL.
Hereditary neuropathy or pain disorder v6.139 NOTCH2NL Sarah Leigh Classified gene: NOTCH2NL as Red List (low evidence)
Hereditary neuropathy or pain disorder v6.139 NOTCH2NL Sarah Leigh Gene: notch2nl has been classified as Red List (Low Evidence).
Hereditary neuropathy or pain disorder v6.138 NOTCH2NL Sarah Leigh reviewed gene: NOTCH2NL: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Hereditary neuropathy or pain disorder v6.131 NOTCH2NL Christopher Record gene: NOTCH2NL was added
gene: NOTCH2NL was added to Hereditary neuropathy or pain disorder. Sources: Literature
Mode of inheritance for gene: NOTCH2NL was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: NOTCH2NL were set to 36948577; 37749855; 34675106
Mode of pathogenicity for gene: NOTCH2NL was set to Other
Review for gene: NOTCH2NL was set to GREEN
Added comment: [NB NOTCH2NL selected from gene drop down as NOTCH2NLC not available]
NOTCH2NLC GGC repeat expansion
Reported pure CMT in 26 cases from Japan (36948577), and 7cases from Taiwan (34675106). Chinese NOTC2NLC related NIID cohort also showed peripheral neuropathy in significant proportion (37749855). Anecdotally found in family with CMT of European ancestry (unpublished).
Phenotypes included CMT2, CMTi and HMN
Sources: Literature