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Familial melanoma v1.12 POT1 Arina Puzriakova Tag for-review was removed from gene: POT1.
Familial melanoma v1.12 POT1 Arina Puzriakova commented on gene: POT1: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Familial melanoma v1.11 POT1 Arina Puzriakova Source Expert Review Green was added to POT1.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Familial melanoma v1.9 POT1 Arina Puzriakova Phenotypes for gene: POT1 were changed from Melanoma, cutaneous malignant, susceptibility to, 10, 615848 to Melanoma, cutaneous malignant, susceptibility to, 10, OMIM:615848
Familial melanoma v1.8 POT1 Arina Puzriakova Publications for gene: POT1 were set to 24686849; 24686846; 29523635; 30451293; 30586141; 32325837
Familial melanoma v1.7 POT1 Arina Puzriakova edited their review of gene: POT1: Changed publications: 24686849, 24686846, 29523635, 30451293, 30586141, 32325837, 32907878
Familial melanoma v1.7 POT1 Arina Puzriakova Tag for-review tag was added to gene: POT1.
Familial melanoma v1.7 POT1 Arina Puzriakova Phenotypes for gene: POT1 were changed from to Melanoma, cutaneous malignant, susceptibility to, 10, 615848
Familial melanoma v1.6 POT1 Arina Puzriakova Publications for gene: POT1 were set to
Familial melanoma v1.5 POT1 Arina Puzriakova Classified gene: POT1 as Amber List (moderate evidence)
Familial melanoma v1.5 POT1 Arina Puzriakova Added comment: Comment on list classification: Based on evidence provided by several publications, POT1 should be considered for a rating upgrade from Amber to Green, and therefore will be flagged for review at the date of next GMS panel update (added 'for-review' tag).
Familial melanoma v1.5 POT1 Arina Puzriakova Gene: pot1 has been classified as Amber List (Moderate Evidence).
Familial melanoma v1.4 POT1 Arina Puzriakova edited their review of gene: POT1: Changed rating: GREEN; Changed mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial melanoma v1.4 POT1 Arina Puzriakova reviewed gene: POT1: Rating: ; Mode of pathogenicity: None; Publications: 24686849, 24686846, 29523635, 30451293, 30586141, 32325837; Phenotypes: Melanoma, cutaneous malignant, susceptibility to, 10, 615848; Mode of inheritance: None
Familial melanoma v0.20 POT1 Ivone Leong Classified gene: POT1 as Amber List (moderate evidence)
Familial melanoma v0.20 POT1 Ivone Leong Added comment: Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Familial melanoma v0.20 POT1 Ivone Leong Gene: pot1 has been classified as Amber List (Moderate Evidence).
Familial melanoma v0.18 POT1 Ivone Leong Classified gene: POT1 as Amber List (moderate evidence)
Familial melanoma v0.18 POT1 Ivone Leong Gene: pot1 has been classified as Amber List (Moderate Evidence).
Familial melanoma v0.16 POT1 Ivone Leong Mode of inheritance for gene: POT1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial melanoma v0.3 POT1 Rachel Robinson reviewed gene: POT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: ; Current diagnostic: yes
Familial melanoma v0.3 POT1 Lara Hawkes reviewed gene: POT1: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Familial melanoma v0.2 POT1 Ivone Leong gene: POT1 was added
gene: POT1 was added to Familial melanoma. Sources: Expert List,NHS GMS
Mode of inheritance for gene: POT1 was set to