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Thrombophilia with a likely monogenic cause v1.17 PROCR Arina Puzriakova Publications for gene: PROCR were set to
Thrombophilia with a likely monogenic cause v0.37 PROCR Louise Daugherty commented on gene: PROCR: Follow up email correspondence with Patricia Bignell 13th March (webex 8.03.19 WWMGLH comments v1.doc), on behalf of Wessex and the West Midlands GLH for the GMS Haematology specialist test group, suggested rating Red
Thrombophilia with a likely monogenic cause v0.36 PROCR Louise Daugherty Source Wessex and West Midlands GLH was added to PROCR.
Thrombophilia with a likely monogenic cause v0.35 PROCR PATRICIA BIGNELL reviewed gene: PROCR: Rating: RED; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Thrombophilia with a likely monogenic cause v0.34 PROCR Louise Daugherty commented on gene: PROCR: Initial gene list (Consensus Genes for SPEC HAEM Panels 31.01.19 North West v1 FINAL.xlsx) collated by Steve Keeney Molecular Diagnostics Centre Central Manchester NHS Foundation Trust January 2019 on behalf of North West GLH for the GMS Haematology specialist test group. Gene Symbol submitted: PROCR; Suggested initial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal; Phenotypes: none submitted; PMID(s): none submitted
Thrombophilia with a likely monogenic cause v0.33 PROCR Steve Keeney reviewed gene: PROCR: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Thrombophilia with a likely monogenic cause v0.30 PROCR Louise Daugherty Source North West GLH was added to PROCR.
Thrombophilia with a likely monogenic cause v0.29 PROCR Louise Daugherty commented on gene: PROCR: Initial gene list (Consensus Genes for Panels_Haem_SHEFFIELD-29.01.2019.xlsx) collated by Mandy Nesbitt Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Trust January 2019 on behalf of Yorkshire and North East GLH for the GMS Haematology specialist test group. Gene Symbol submitted: PROCR; Suggested intial gene rating: I don't know; Are variants in this gene part of your current diagnostic practice? No; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal; Phenotypes: Thrombophilia; PMID(s): none submitted
Thrombophilia with a likely monogenic cause v0.28 PROCR Mandy nesbitt reviewed gene: PROCR: Rating: AMBER; Mode of pathogenicity: ; Publications: 24051141; Phenotypes: ?Thrombophilia; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Thrombophilia with a likely monogenic cause v0.27 PROCR Louise Daugherty Added phenotypes ?Thrombophilia for gene: PROCR
Thrombophilia with a likely monogenic cause v0.25 PROCR Louise Daugherty Source Yorkshire and North East GLH was added to PROCR.
Thrombophilia with a likely monogenic cause v0.20 PROCR Louise Daugherty Mode of inheritance for gene: PROCR was changed from to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Thrombophilia with a likely monogenic cause v0.19 PROCR Louise Daugherty Classified gene: PROCR as Amber List (moderate evidence)
Thrombophilia with a likely monogenic cause v0.19 PROCR Louise Daugherty Gene: procr has been classified as Amber List (Moderate Evidence).
Thrombophilia with a likely monogenic cause v0.12 PROCR Louise Daugherty reviewed gene: PROCR: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Thrombophilia with a likely monogenic cause v0.11 PROCR Michael Mitchell reviewed gene: PROCR: Rating: AMBER; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Thrombophilia with a likely monogenic cause v0.9 PROCR Louise Daugherty Source NHS GMS was added to PROCR.
Thrombophilia with a likely monogenic cause v0.8 PROCR Louise Daugherty gene: PROCR was added
gene: PROCR was added to Thrombophilia. Sources: London South GLH
Mode of inheritance for gene: PROCR was set to