Activity
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12 actions
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| Haematological malignancies cancer susceptibility v4.40 | TCF3 |
Arina Puzriakova Tag Q2_25_ promote_green was removed from gene: TCF3. Tag Q2_25_expert_review was removed from gene: TCF3. |
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| Haematological malignancies cancer susceptibility v4.40 | TCF3 | Arina Puzriakova edited their review of gene: TCF3: Changed rating: AMBER | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.39 | TCF3 | Arina Puzriakova commented on gene: TCF3: After NHS Genomic Medicine Service consideration, the rating of this gene has not been changed and remains amber. Additional comments from reviewing GLHs: no clinical guidelines to manage the findings. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.36 | TCF3 | Arina Puzriakova Phenotypes for gene: TCF3 were changed from B-cell acute lymphoblastic leukemia to B-cell acute lymphoblastic leukemia, MONDO:0004947 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.35 | TCF3 | Arina Puzriakova Added comment: Comment on mode of inheritance: Updated MOI to monoallelic - PMID: 36576946 states that 'The allele fraction of each variant in each sample was confirmed to be ∼50%, consistent with a heterozygous genotype.' | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.35 | TCF3 | Arina Puzriakova Mode of inheritance for gene: TCF3 was changed from BOTH monoallelic and biallelic, autosomal or pseudoautosomal to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.8 | TCF3 |
Sarah Leigh Tag Q2_25_ promote_green tag was added to gene: TCF3. Tag Q2_25_expert_review tag was added to gene: TCF3. |
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| Haematological malignancies cancer susceptibility v4.8 | TCF3 | Sarah Leigh reviewed gene: TCF3: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: B-cell acute lymphoblastic leukemia, MONDO:0004947; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.8 | TCF3 | Sarah Leigh Publications for gene: TCF3 were set to 36576946 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.7 | TCF3 | Sarah Leigh Classified gene: TCF3 as Amber List (moderate evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.7 | TCF3 | Sarah Leigh Gene: tcf3 has been classified as Amber List (Moderate Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Haematological malignancies cancer susceptibility v4.2 | TCF3 |
Lauma Freimane gene: TCF3 was added gene: TCF3 was added to Haematological malignancies cancer susceptibility. Sources: Literature Mode of inheritance for gene: TCF3 was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: TCF3 were set to 36576946 Phenotypes for gene: TCF3 were set to B-cell acute lymphoblastic leukemia Penetrance for gene: TCF3 were set to unknown Review for gene: TCF3 was set to GREEN gene: TCF3 was marked as current diagnostic Added comment: Autors hypothesize that variants in TCF3 gene alter B-cell maturation which may increase the risk for preleukemic clone emergence (PMID: 36576946). Sources: Literature |
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