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Hereditary spastic paraplegia v1.253 TFG Arina Puzriakova Phenotypes for gene: TFG were changed from Hereditary spastic paraplegia - childhood onset; Intellectual disability; Hereditary spastic paraplegia - adult onset; neuropathy to Spastic paraplegia 57, autosomal recessive, OMIM:615658
Hereditary spastic paraplegia v1.252 TFG Arina Puzriakova Publications for gene: TFG were set to 23479643; 27601211; 28124177; 27492651
Hereditary spastic paraplegia v1.213 TFG Louise Daugherty edited their review of gene: TFG: Changed rating: GREEN
Hereditary spastic paraplegia v1.213 TFG Louise Daugherty Classified gene: TFG as Green List (high evidence)
Hereditary spastic paraplegia v1.213 TFG Louise Daugherty Added comment: Comment on list classification: Upgraded gene from Amber to Green due to feedback from Genomics England clinical team, due to re-analysing a few cases for diagnostic discovery there is enough evidence to support a Green rating on this panel.
Hereditary spastic paraplegia v1.213 TFG Louise Daugherty Gene: tfg has been classified as Green List (High Evidence).
Hereditary spastic paraplegia v1.212 TFG Louise Daugherty Phenotypes for gene: TFG were changed from to Hereditary spastic paraplegia - childhood onset; Intellectual disability; Hereditary spastic paraplegia - adult onset; neuropathy
Hereditary spastic paraplegia v1.211 TFG Louise Daugherty Added comment: Comment on publications: added publications to support upgrading from Amber to Green.
Hereditary spastic paraplegia v1.211 TFG Louise Daugherty Publications for gene: TFG were set to Beetz et al. (2013)
Hereditary spastic paraplegia v1.210 TFG Zerin Hyder reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 23479643, 27601211, 28124177, 27492651; Phenotypes: Hereditary spastic paraplegia - childhood onset, Intellectual disability, Hereditary spastic paraplegia - adult onset; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Hereditary spastic paraplegia v1.203 TFG Louise Daugherty reviewed gene: TFG: Rating: AMBER; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Hereditary spastic paraplegia v1.203 TFG Louise Daugherty Classified gene: TFG as Amber List (moderate evidence)
Hereditary spastic paraplegia v1.203 TFG Louise Daugherty Gene: tfg has been classified as Amber List (Moderate Evidence).
Hereditary spastic paraplegia v1.71 TFG Chris Buxton reviewed gene: TFG: Rating: GREEN; Mode of pathogenicity: None; Publications: 23479643, 27492651, 27601211; Phenotypes: spastic paraplegia, optic atrophy, neuropathy; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal