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Primary immunodeficiency or monogenic inflammatory bowel disease v4.50 TNFRSF9 Arina Puzriakova Phenotypes for gene: TNFRSF9 were changed from CD137 deficiency (41BB); EBV lymphoproliferation, B-cell lymphoma to Immunodeficiency 109 with lymphoproliferation, OMIM:620282
Primary immunodeficiency or monogenic inflammatory bowel disease v4.49 TNFRSF9 Arina Puzriakova Tag gene-checked was removed from gene: TNFRSF9.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.548 TNFRSF9 Catherine Snow Tag gene-checked tag was added to gene: TNFRSF9.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 TNFRSF9 Arina Puzriakova Tag for-review was removed from gene: TNFRSF9.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.529 TNFRSF9 Arina Puzriakova commented on gene: TNFRSF9: The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.528 TNFRSF9 Arina Puzriakova Source Expert Review Green was added to TNFRSF9.
Rating Changed from Amber List (moderate evidence) to Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.361 TNFRSF9 Arina Puzriakova Classified gene: TNFRSF9 as Amber List (moderate evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.361 TNFRSF9 Arina Puzriakova Added comment: Comment on list classification: Changed rating from Green to Amber so that Green genes on this panel reflect the NHS signed-off version. This will be reviewed at the next GMS panel update (added 'for-review' tag).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.361 TNFRSF9 Arina Puzriakova Gene: tnfrsf9 has been classified as Amber List (Moderate Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.360 TNFRSF9 Arina Puzriakova Tag for-review tag was added to gene: TNFRSF9.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.75 TNFRSF9 Ivone Leong Classified gene: TNFRSF9 as Green List (high evidence)
Primary immunodeficiency or monogenic inflammatory bowel disease v2.75 TNFRSF9 Ivone Leong Added comment: Comment on list classification: Promoted from Red to Green based on expert review and evidence.
Primary immunodeficiency or monogenic inflammatory bowel disease v2.75 TNFRSF9 Ivone Leong Gene: tnfrsf9 has been classified as Green List (High Evidence).
Primary immunodeficiency or monogenic inflammatory bowel disease v2.51 TNFRSF9 Zornitza Stark reviewed gene: TNFRSF9: Rating: GREEN; Mode of pathogenicity: None; Publications: 30872117, 31501153; Phenotypes: EBV lymphoproliferation, B-cell lymphoma, Chronic active EBV infection; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal; Current diagnostic: yes
Primary immunodeficiency or monogenic inflammatory bowel disease v2.36 TNFRSF9 Louise Daugherty reviewed gene: TNFRSF9: Rating: AMBER; Mode of pathogenicity: ; Publications: 31537641, 30872117, 31501153; Phenotypes: ; Mode of inheritance:
Primary immunodeficiency or monogenic inflammatory bowel disease v2.35 TNFRSF9 Louise Daugherty Publications for gene TNFRSF9 were updated from 32048120; 32086639 to 30872117; 32086639; 31537641; 31501153; 32048120
Primary immunodeficiency or monogenic inflammatory bowel disease v2.13 TNFRSF9 Louise Daugherty gene: TNFRSF9 was added
gene: TNFRSF9 was added to Primary immunodeficiency. Sources: IUIS Classification December 2019
Mode of inheritance for gene: TNFRSF9 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: TNFRSF9 were set to 32048120; 32086639
Phenotypes for gene: TNFRSF9 were set to CD137 deficiency (41BB); EBV lymphoproliferation, B-cell lymphoma