Activity

Filter

Cancel
Date Panel Item Activity
1 actions
Adult onset neurodegenerative disorder v9.1 TRPV4 Oliver Ziff gene: TRPV4 was added
gene: TRPV4 was added to Adult onset neurodegenerative disorder. Sources: Literature,Expert Review
Mode of inheritance for gene: TRPV4 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: TRPV4 were set to 20037586
Phenotypes for gene: TRPV4 were set to Hereditary motor and sensory neuropathy, type IIc, 606071
Penetrance for gene: TRPV4 were set to Complete
Mode of pathogenicity for gene: TRPV4 was set to Other
Review for gene: TRPV4 was set to GREEN
gene: TRPV4 was marked as current diagnostic
Added comment: Causes scapuloperoneal SMA and dHMN. The progressive motor weakness frequently mimics LMN-predominant MND, necessitating upfront R460.1 screening. Inclusion prevents sequential WGS reanalysis on R460.1 requests.
Sources: Literature, Expert Review