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Li Fraumeni Syndrome v1.5 TP53 Achchuthan Shanmugasundram Added comment: Comment on phenotypes: This gene has been associated with relevant phenotypes in OMIM (MIM #151623) and the OMIM record was last accessed on 20 December 2025.
Li Fraumeni Syndrome v1.5 TP53 Achchuthan Shanmugasundram Phenotypes for gene: TP53 were changed from to Li-Fraumeni syndrome, OMIM:151623; Li-Fraumeni syndrome, MONDO:0018875
Li Fraumeni Syndrome v1.4 POT1 Achchuthan Shanmugasundram Added comment: Comment on phenotypes: This gene has been associated with relevant phenotypes in OMIM (MIMs #61584 & #620367) and the OMIM records were last accessed on 20 December 2025.
Li Fraumeni Syndrome v1.4 POT1 Achchuthan Shanmugasundram Phenotypes for gene: POT1 were changed from to Tumor predisposition syndrome 3, OMIM:615848; ?Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8, OMIM:620367; tumor predisposition syndrome 3, MONDO:0014368
Li Fraumeni Syndrome v1.1 Achchuthan Shanmugasundram Panel version 1.0 has been signed off on 2023-03-22
Li Fraumeni Syndrome v1.0 Achchuthan Shanmugasundram promoted panel to version 1.0
Li Fraumeni Syndrome v0.9 Achchuthan Shanmugasundram Panel types changed to GMS Rare Disease; GMS signed-off
Li Fraumeni Syndrome v0.8 Sarah Leigh Panel status changed from internal to public
Panel types changed to GMS Rare Disease
Li Fraumeni Syndrome v0.7 POT1 Sarah Leigh reviewed gene: POT1: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Li Fraumeni Syndrome v0.6 POT1 Sarah Leigh gene: POT1 was added
gene: POT1 was added to Li Fraumeni Syndrome. Sources: Expert Review Green,NHS GMS
Mode of inheritance for gene: POT1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Li Fraumeni Syndrome v0.5 Eleanor Williams Panel status changed from public to internal
Li Fraumeni Syndrome v0.4 Eleanor Williams Panel status changed from internal to public
Panel types changed to
Li Fraumeni Syndrome v0.3 TP53 Eleanor Williams reviewed gene: TP53: Rating: ; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Li Fraumeni Syndrome v0.2 TP53 Eleanor Williams gene: TP53 was added
gene: TP53 was added to Li Fraumeni Syndrome. Sources: Expert Review Green,NHS GMS
Mode of inheritance for gene: TP53 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Li Fraumeni Syndrome v0.1 Eleanor Williams Panel types changed to GMS Rare Disease
Li Fraumeni Syndrome v0.0 Eleanor Williams Added Panel Li Fraumeni Syndrome
Set list of related panels to R216