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Inherited breast cancer and ovarian cancer v2.7 RAD51D Achchuthan Shanmugasundram Source NHS GMS was added to RAD51D.
Inherited breast cancer and ovarian cancer v2.7 RAD51C Achchuthan Shanmugasundram Source NHS GMS was added to RAD51C.
Inherited breast cancer and ovarian cancer v2.6 Eleanor Williams Panel version 2.5 has been signed off on 2023-04-12
Inherited breast cancer and ovarian cancer v2.5 RAD51D Eleanor Williams commented on gene: RAD51D
Inherited breast cancer and ovarian cancer v2.5 RAD51D Eleanor Williams Classified gene: RAD51D as Green List (high evidence)
Inherited breast cancer and ovarian cancer v2.5 RAD51D Eleanor Williams Gene: rad51d has been classified as Green List (High Evidence).
Inherited breast cancer and ovarian cancer v2.4 RAD51D Eleanor Williams gene: RAD51D was added
gene: RAD51D was added to Inherited breast cancer and ovarian cancer. Sources: Expert list
Mode of inheritance for gene: RAD51D was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes for gene: RAD51D were set to {Breast-ovarian cancer, familial, susceptibility to, 4}, OMIM:614291
Inherited breast cancer and ovarian cancer v2.3 RAD51C Eleanor Williams commented on gene: RAD51C
Inherited breast cancer and ovarian cancer v2.3 RAD51C Eleanor Williams Classified gene: RAD51C as Green List (high evidence)
Inherited breast cancer and ovarian cancer v2.3 RAD51C Eleanor Williams Gene: rad51c has been classified as Green List (High Evidence).
Inherited breast cancer and ovarian cancer v2.2 RAD51C Eleanor Williams gene: RAD51C was added
gene: RAD51C was added to Inherited breast cancer and ovarian cancer. Sources: Expert list
Mode of inheritance for gene: RAD51C was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes for gene: RAD51C were set to {Breast-ovarian cancer, familial, susceptibility to, 3}, OMIM:613399
Inherited breast cancer and ovarian cancer v2.1 Arina Puzriakova Panel version 2.0 has been signed off on 2023-03-22
Inherited breast cancer and ovarian cancer v2.0 Arina Puzriakova promoted panel to version 2.0
Inherited breast cancer and ovarian cancer v1.3 BRCA1 Arina Puzriakova Tag Q2_22_MOI was removed from gene: BRCA1.
Tag Q2_22_expert_review was removed from gene: BRCA1.
Inherited breast cancer and ovarian cancer v1.3 BRCA1 Arina Puzriakova Source NHS GMS was added to BRCA1.
Mode of inheritance for gene BRCA1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Inherited breast cancer and ovarian cancer v1.2 BRCA1 Arina Puzriakova commented on gene: BRCA1: The mode of inheritance of this gene has been updated to 'BOTH monoallelic and biallelic, autosomal or pseudoautosomal' following NHS Genomic Medicine Service approval.
Inherited breast cancer and ovarian cancer v1.1 Catherine Snow Panel types changed to GMS Rare Disease; GMS signed-off
Panel version 1.0 has been signed off on 2022-11-30
Inherited breast cancer and ovarian cancer v1.0 Catherine Snow promoted panel to version 1.0
Inherited breast cancer and ovarian cancer v0.18 Eleanor Williams Panel status changed from internal to public
Inherited breast cancer and ovarian cancer v0.17 BRCA1 Arina Puzriakova Added comment: Comment on mode of inheritance: Although more rare, biallelic germline BRCA1 variants have been shown to also confer breast and ovarian cancer susceptibility (with or without FA‐like features), and multiple such cases have been reported worldwide (PMIDs: 23269703; 25472942; 31347298; 33477375).

This may warrant an MOI change from 'monoallelic' to 'both mono- and biallelic' to ensure these rarer cases are not missed; however this will be flagged for further review to confirm whether the GMS expert group agrees with the change.
Inherited breast cancer and ovarian cancer v0.17 BRCA1 Arina Puzriakova Mode of inheritance for gene: BRCA1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Inherited breast cancer and ovarian cancer v0.16 BRCA1 Arina Puzriakova Tag Q2_22_MOI tag was added to gene: BRCA1.
Tag Q2_22_expert_review tag was added to gene: BRCA1.
Inherited breast cancer and ovarian cancer v0.16 PALB2 Arina Puzriakova Phenotypes for gene: PALB2 were changed from Fanconi anemia, complementation group N, 610832; High Risk Breast Cancer; {Pancreatic cancer, susceptibility to, 3}, 613348; Breast and Ovarian Cancer; {Breast cancer, susceptibility to}, 114480 to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.15 BRCA2 Arina Puzriakova Phenotypes for gene: BRCA2 were changed from Breast and Ovarian Cancer; Breast cancer; {Breast cancer, male, susceptibility to}, 114480; Hereditary Breast and Ovarian Cancer Syndrome; {Glioblastoma 3},; Hereditary Breast and Ovarian Cancer; {Medulloblastoma}, 155255; Prostate cancer, 176807; {Breast-ovarian cancer, familial, 2}, 612555; High Risk Breast Cancer; Fanconi anemia, complementation group D1, 605724; Wilms tumor, 194070 to {Breast-ovarian cancer, familial, 2}, OMIM:612555
Inherited breast cancer and ovarian cancer v0.14 BRCA1 Arina Puzriakova Phenotypes for gene: BRCA1 were changed from {Breast-ovarian cancer, familial, 1}, 604370; Breast and Ovarian Cancer; {Pancreatic cancer, susceptibility to, 4}, 614320; Breast cancer; Hereditary Breast and Ovarian Cancer Syndrome; Hereditary Breast and Ovarian Cancer; High Risk Breast Cancer to {Breast-ovarian cancer, familial, 1}, OMIM:604370
Inherited breast cancer and ovarian cancer v0.13 ATM Arina Puzriakova Publications for gene: ATM were set to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.12 CHEK2 Arina Puzriakova Publications for gene: CHEK2 were set to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.11 ATM Arina Puzriakova Phenotypes for gene: ATM were changed from to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.10 CHEK2 Arina Puzriakova Phenotypes for gene: CHEK2 were changed from to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.9 CHEK2 Arina Puzriakova reviewed gene: CHEK2: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Inherited breast cancer and ovarian cancer v0.9 ATM Arina Puzriakova reviewed gene: ATM: Rating: GREEN; Mode of pathogenicity: ; Publications: ; Phenotypes: ; Mode of inheritance:
Inherited breast cancer and ovarian cancer v0.8 CHEK2 Arina Puzriakova gene: CHEK2 was added
gene: CHEK2 was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green
Mode of inheritance for gene: CHEK2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: CHEK2 were set to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.8 ATM Arina Puzriakova gene: ATM was added
gene: ATM was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green
Mode of inheritance for gene: ATM was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: ATM were set to {Breast cancer, susceptibility to}, OMIM:114480
Inherited breast cancer and ovarian cancer v0.7 Ellen McDonagh Panel status changed from public to internal
Inherited breast cancer and ovarian cancer v0.5 Ellen McDonagh Panel status changed from internal to public
Inherited breast cancer and ovarian cancer v0.4 Ellen McDonagh List of related panels changed from to R208
Inherited breast cancer and ovarian cancer v0.1 PALB2 Ellen McDonagh gene: PALB2 was added
gene: PALB2 was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green
Mode of inheritance for gene: PALB2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: PALB2 were set to Fanconi anemia, complementation group N, 610832; High Risk Breast Cancer; {Pancreatic cancer, susceptibility to, 3}, 613348; Breast and Ovarian Cancer; {Breast cancer, susceptibility to}, 114480
Inherited breast cancer and ovarian cancer v0.1 BRCA2 Ellen McDonagh gene: BRCA2 was added
gene: BRCA2 was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green
Mode of inheritance for gene: BRCA2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: BRCA2 were set to Breast and Ovarian Cancer; Breast cancer; {Breast cancer, male, susceptibility to}, 114480; Hereditary Breast and Ovarian Cancer Syndrome; {Glioblastoma 3},; Hereditary Breast and Ovarian Cancer; {Medulloblastoma}, 155255; Prostate cancer, 176807; {Breast-ovarian cancer, familial, 2}, 612555; High Risk Breast Cancer; Fanconi anemia, complementation group D1, 605724; Wilms tumor, 194070
Inherited breast cancer and ovarian cancer v0.1 BRCA1 Ellen McDonagh gene: BRCA1 was added
gene: BRCA1 was added to Inherited breast cancer and ovarian cancer. Sources: Expert Review Green
Mode of inheritance for gene: BRCA1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes for gene: BRCA1 were set to {Breast-ovarian cancer, familial, 1}, 604370; Breast and Ovarian Cancer; {Pancreatic cancer, susceptibility to, 4}, 614320; Breast cancer; Hereditary Breast and Ovarian Cancer Syndrome; Hereditary Breast and Ovarian Cancer; High Risk Breast Cancer
Inherited breast cancer and ovarian cancer v0.0 Ellen McDonagh Added Panel Inherited breast cancer and ovarian cancer
Set panel types to: GMS Rare Disease