1. Genes and Genomic Entities
  2. ADAMTS10

ADAMTS10

ADAM metallopeptidase with thrombospondin type 1 motif 10
OMIM: 608990, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
Green ADAMTS10 in Glaucoma (developmental)

Level 3: Anterior segment abnormalities
Level 2: Ophthalmological disorders
Version 1.47

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Green
  • GDL Glaucoma panel
Phenotypes
  • Weill-Marchesani syndrome 1, recessive
Green ADAMTS10 in Bilateral congenital or childhood onset cataracts


Level 2: Ophthalmology
Version 8.1
Latest signed off version: v8.0 (6 May 2026)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • UKGTN
Phenotypes
  • Weill-Marchesani syndrome
Green ADAMTS10 in Arthrogryposis


Level 2: Neurology
Version 10.7
Latest signed off version: v10.0 (6 May 2026)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Weill-Marchesani syndrome 1, recessive 277600
Green ADAMTS10 in Skeletal dysplasia


Level 2: Musculoskeletal
Version 9.13
Latest signed off version: v9.0 (6 May 2026)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Weill-Marchesani syndrome 1, recessive, 277600
    Green ADAMTS10 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 7.11
    Latest signed off version: v7.0 (6 May 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • PAGE Additional Gene List
    • Expert Review Green
    Phenotypes
    • Weill-Marchesani syndrome 1, recessive 277600
    Amber ADAMTS10 in Intellectual disability


    Level 2: Developmental disorders
    Version 10.18
    Latest signed off version: v10.0 (6 May 2026)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    • Expert list
    Phenotypes
    • Weill-Marchesani syndrome 1, recessive, MIM#277600
    Green ADAMTS10 in Structural eye disease


    Level 2: Ophthalmology
    Version 5.6
    Latest signed off version: v5.0 (6 May 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Weill-Marchesani syndrome 1, recessive