CD46

CD46 molecule
OMIM: 120920, Gene2Phenotype

5 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 5 panels
Green CD46 in COVID-19 research Level 2: Viral research Version 1.146	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources IUIS Classification February 2018 London North GLH NHS GMS GRID V2.0 Victorian Clinical Genetics Services North West GLH ESID Registry 20171117 Expert Review Green NHS GMS North West GLH London North GLH Expert Review Green IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 Phenotypes Hemolytic uremic syndrome, atypical, susceptibility to, 2, 612922 atypical HUS Membrane Cofactor Protein (CD46) deficiency Complement Deficiencies Atypical hemolytic-uremic syndrome, infections, preeclampsia
Red CD46 in Membranoproliferative glomerulonephritis including C3 glomerulopathy Level 2: Renal Version 3.8 Latest signed off version: v3.6 (30 Apr 2025) Component of the following Super Panels: Unexplained young onset end-stage renal disease	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red Expert list Phenotypes Haemolytic uraemic syndrome aHUS Hemolytic uremic syndrome, atypical, susceptibility to, 2, 612922 C3 glomerulopathy C3G Immune complex MPGN IC-MPGN
Green CD46 in Atypical haemolytic uraemic syndrome Level 2: Renal Version 3.8 Latest signed off version: v3.6 (30 Apr 2025) Component of the following Super Panels: Unexplained young onset end-stage renal disease	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Eligibility statement prior genetic testing Phenotypes Hemolytic uremic syndrome, atypical, susceptibility to, 2 612922
Green CD46 in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.78 Latest signed off version: v8.0 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS North West GLH London North GLH Expert Review Green IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 Phenotypes Hemolytic uremic syndrome, atypical, susceptibility to, 2, 612922 Membrane Cofactor Protein (CD46) deficiency atypical HUS Atypical hemolytic-uremic syndrome, infections, preeclampsia Complement Deficiencies
Green CD46 in Unexplained kidney failure in young people Level 3: Disorders of function Level 2: Renal and urinary tract disorders Version 1.124	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green Illumina TruGenome Clinical Sequencing Services Expert Review UKGTN Expert list Phenotypes Hemolytic uremic syndrome, atypical, susceptibility to, 2 612922