1. Genes and Genomic Entities
  2. CFH

CFH

complement factor H
OMIM: 134370, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green CFH in COVID-19 research


Level 2: Viral research
Version 1.146

review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • London North GLH
  • NHS GMS
  • Inherited complement deficiency v0.11
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • Expert Review Green
  • ESID Registry 20171117
  • GRID V2.0
  • Inherited complement deficiency v0.11
Phenotypes
  • Complement Deficiencies
  • Complement factor H deficiency, 609814
  • Infections, disseminated neisserial infections, atypical Hemolytic-uremic syndrome, preeclampsia, dense deposit disease
Green CFH in Membranoproliferative glomerulonephritis including C3 glomerulopathy


Level 2: Renal
Version 3.8
Latest signed off version: v3.6 (30 Apr 2025)

Component of the following Super Panels:

  • Unexplained young onset end-stage renal disease

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    • Expert list
    Phenotypes
    • C3 glomerulopathy
    • C3G
    • Immune complex MPGN
    • IC-MPGN
    • Hemolytic uremic syndrome, atypical, susceptibility to, 1, 235400
    • Dense Deposit Disease
    • Membranoproliferative Glomerulonephritis Type II
    • Immune-complex-mediated MPGN
    Green CFH in Atypical haemolytic uraemic syndrome


    Level 2: Renal
    Version 3.8
    Latest signed off version: v3.6 (30 Apr 2025)

    Component of the following Super Panels:

  • Unexplained young onset end-stage renal disease

    		•  review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    • UKGTN
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    • Eligibility statement prior genetic testing
    Phenotypes
    • Hemolytic uremic syndrome, atypical, susceptibility to, 1 235400
    Green CFH in Primary immunodeficiency or monogenic inflammatory bowel disease


    Level 2: Immunology
    Version 8.78
    Latest signed off version: v8.0 (30 Apr 2025)

    		review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • North West GLH
    • London North GLH
    • IUIS Classification February 2018
    • Victorian Clinical Genetics Services
    • Expert Review Green
    • ESID Registry 20171117
    • GRID V2.0
    • Inherited complement deficiency v0.11
    Phenotypes
    • Complement factor H deficiency, 609814
    • Infections, disseminated neisserial infections, atypical Hemolytic-uremic syndrome, preeclampsia, dense deposit disease
    • Complement Deficiencies
    Green CFH in Unexplained kidney failure in young people

    Level 3: Disorders of function
    Level 2: Renal and urinary tract disorders
    Version 1.124

    		review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert list
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    • UKGTN
    • Illumina TruGenome Clinical Sequencing Services
    Phenotypes
    • Complement factor H deficiency 609814
    • {Hemolytic uremic syndrome, atypical, susceptibility to, 1} 235400
    Green CFH in Retinal disorders


    Level 2: Ophthalmology
    Version 8.86
    Latest signed off version: v8.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • {Macular degeneration, age-related, 4} 610698
    • Basal laminar drusen, 126700