DICER1

dicer 1, ribonuclease III
OMIM: 606241, Gene2Phenotype

11 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 11 panels
Green DICER1 in ClinGen Gene Validity Curations Version 0.65	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources ClinGen Expert Review Green Other Phenotypes Pleuropulmonary Blastoma ORPHA64742 OMIM 601200
Green DICER1 in Inherited non-medullary thyroid cancer Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.7	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Radboud University Medical Center, Nijmegen Phenotypes Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800
Green DICER1 in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.40	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes DICER1 syndrome, Familial Multinodular Goiter
Green DICER1 in COVID-19 research Level 2: Viral research Version 1.142	review	Unknown	Sources Expert Review Green OMIM Expert list
Red DICER1 in Familial rhabdomyosarcoma Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.5	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red Literature Phenotypes Pleuropulmonary blastoma, 601200 Rhabdomyosarcoma, embryonal, 2, 180295
Green DICER1 in Childhood solid tumours Level 3: Childhood Tumours Level 2: Tumour syndromes Version 4.18 Latest signed off version: v4.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert List Expert Review Green Expert list Phenotypes Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800 Pleuropulmonary blastoma, OMIM:601200 Pleuropulmonary blastoma, MONDO:0011014 Rhabdomyosarcoma, embryonal, 2, OMIM:180295 Embryonal rhabdomyosarcoma (disease), MONDO:0009993 DICER1 syndrome GLOW syndrome Global developmental delay, lung cysts, overgrowth, and wilms tumor, MONDO:0032647
Red DICER1 in Sarcoma cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.25	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red Literature Phenotypes Pleuropulmonary blastoma, 601200 Rhabdomyosarcoma, embryonal, 2, 180295
Green DICER1 in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.27	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes DICER1 syndrome Familial Multinodular Goiter
Green DICER1 in Adult solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 2.29 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors, OMIM:138800 Pleuropulmonary blastoma, OMIM:601200 Pleuropulmonary blastoma, MONDO:0011014 Rhabdomyosarcoma, embryonal, 2, OMIM:180295 Embryonal rhabdomyosarcoma (disease), MONDO:0009993 DICER1 syndrome
Red DICER1 in Sarcoma susceptibility Version 1.81 Latest signed off version: v1.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Red Expert Review Red Literature Phenotypes Pleuropulmonary blastoma, OMIM:601200 Pleuropulmonary blastoma, MONDO:0011014 Rhabdomyosarcoma, embryonal, 2, OMIM:180295 Embryonal rhabdomyosarcoma (disease), MONDO:0009993
Green DICER1 in DICER1-related cancer predisposition Version 1.1 Latest signed off version: v1.0 (14 Sep 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources NHS GMS Expert Review Green