DMD

dystrophin
OMIM: 300377, Gene2Phenotype

19 panels

Panel Reviews Mode of inheritance Details
19 panels
Red DMD in Distal myopathies


Level 2: Neurology
Version 6.16
Latest signed off version: v6.4 (30 Apr 2025)

Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review Not set
    Sources
    • Expert Review Red
    • Eligibility statement prior genetic testing
    Tags
    • Skewed X-inactivation
    Red DMD in COVID-19 research


    Level 2: Viral research
    Version 1.146

    review Not set
    Sources
    • OMIM
    Tags
    • Skewed X-inactivation
    Green DMD in Gastrointestinal neuromuscular disorders

    Level 3: Gastrointestinal disorders
    Level 2: Gastroenterological disorders
    Version 1.30

    review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Duchenne muscular dystrophy 310200
    Tags
    • gene-therapy-trial
    • Skewed X-inactivation
    Green DMD in Rhabdomyolysis and metabolic muscle disorders


    Level 2: Neurology
    Version 5.14
    Latest signed off version: v5.4 (30 Apr 2025)

    Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Expert Review Green
    • Illumina TruGenome Clinical Sequencing Services
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    • UKGTN
    Phenotypes
    • Becker muscular dystrophy 300376
    Tags
    • gene-therapy-trial
    • Skewed X-inactivation
    Green DMD in Dilated Cardiomyopathy and conduction defects

    Level 3: Cardiomyopathy
    Level 2: Cardiovascular disorders
    Version 1.97

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • South West GLH
    • London South GLH
    • Expert Review Green
    • Illumina TruGenome Clinical Sequencing Services
    • Expert list
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    Phenotypes
    • Cardiomyopathy, dilated, 3B
    • Dilated Cardiomyopathy, X-Linked
    Tags
    • Skewed X-inactivation
    Green DMD in Congenital muscular dystrophy


    Level 2: Neurology
    Version 6.8
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • NHS GMS
    • Expert Review Green
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    • UKGTN
    Phenotypes
    • Becker muscular dystrophy, OMIM:300376
    • Duchenne muscular dystrophy, OMIM:310200
    Tags
    • gene-therapy-trial
    • Skewed X-inactivation
    Red DMD in Arthrogryposis


    Level 2: Neurology
    Version 9.24
    Latest signed off version: v9.0 (30 Apr 2025)

    review Not set
    Sources
    • Expert Review Red
    • UKGTN
    • Emory Genetics Laboratory
    • Radboud University Medical Center, Nijmegen
    • Expert list
    Phenotypes
    • Duchenne muscular dystrophy, 310200Becker muscular dystrophy, 300376Cardiomyopathy, dilated, 3B, 302045
    • Duchenne or Becker muscular dystrophy
    Tags
    • Skewed X-inactivation
    Green DMD in Limb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies


    Level 2: Neurology
    Version 5.29
    Latest signed off version: v5.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Hypotonic infant
  • Other rare neuromuscular disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Eligibility statement prior genetic testing
    Phenotypes
    • Duchenne muscular dystrophy 310200
    • Becker muscular dystrophy 300376
    Tags
    • gene-therapy-trial
    • Skewed X-inactivation
    Green DMD in Dilated and arrhythmogenic cardiomyopathy


    Level 2: Cardiology
    Version 3.11
    Latest signed off version: v3.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Literature
    • NHS GMS
    Phenotypes
    • Becker muscular dystrophy, 300376
    • Cardiomyopathy, dilated, 3B, 302045
    • Duchenne muscular dystrophy, 310200
    Tags
    • Skewed X-inactivation
    No list DMD in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.138
    Latest signed off version: v6.0 (30 Apr 2025)

    review Not set
    Sources
    • Expert Review Removed
    Tags
    • Skewed X-inactivation
    Green DMD in DDG2P


    Version 6.424
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • DUCHENNE MUSCULAR DYSTROPHY 310200
    • BECKER MUSCULAR DYSTROPHY 300376
    • CARDIOMYOPATHY DILATED X-LINKED TYPE 3B 302045
    Tags
    • Skewed X-inactivation
    Red DMD in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.506

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    Phenotypes
    • Cardiomyopathy
    Tags
    • Skewed X-inactivation
    Red DMD in Monogenic hearing loss


    Level 2: Audiology
    Version 5.57
    Latest signed off version: v5.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review Not set
    Sources
    • Expert
    Tags
    • Skewed X-inactivation
    Green DMD in Intellectual disability


    Level 2: Developmental disorders
    Version 9.279
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    Phenotypes
    • Duchenne muscular dystrophy, 310200Becker muscular dystrophy, 300376Cardiomyopathy, dilated, 3B, 302045
    • BECKER MUSCULAR DYSTROPHY (BMD)
    Tags
    • gene-therapy-trial
    • Skewed X-inactivation
    Amber DMD in Retinal disorders


    Level 2: Ophthalmology
    Version 8.86
    Latest signed off version: v8.0 (30 Apr 2025)

    review Not set
    Sources
    • NHS GMS
    • RetNet
    • Expert Review Amber
    Tags
    • Skewed X-inactivation
    Green DMD in Paediatric or syndromic cardiomyopathy


    Level 2: Cardiology
    Version 7.96
    Latest signed off version: v7.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Unexplained death in infancy and sudden unexplained death in childhood
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • South West GLH
    • Expert Review Green
    Phenotypes
    • Duchenne muscular dystrophy, 310200
    • Dilated Cardiomyopathy, X-Linked
    • Cardiomyopathy, dilated, 3B
    • Becker muscular dystrophy, 300376
    Tags
    • Skewed X-inactivation
    Red DMD in Hereditary neuropathy or pain disorder


    Level 2: Neurology
    Version 7.36
    Latest signed off version: v7.0 (30 Apr 2025)

    review Not set
    Sources
    • NHS GMS
    • South West GLH
    • Emory Genetics Laboratory
    • NHS GMS
    • South West GLH
    Phenotypes
    • Cardiomyopathy
    Tags
    • Skewed X-inactivation
    Green DMD in Acute rhabdomyolysis


    Level 2: Neurology
    Version 2.7
    Latest signed off version: v2.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Becker muscular dystrophy, OMIM:300376
    • Exercise induced cramps and myoglobinuria
    Green DMD in Duchenne or Becker muscular dystrophy


    Level 2: Neurology
    Version 1.3
    Latest signed off version: v1.0 (14 Sep 2023)

    review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Duchenne muscular dystrophy, OMIM:310200
    • Becker muscular dystrophy, OMIM:300376
    • Duchenne muscular dystrophy, MONDO:0010679
    • Becker muscular dystrophy, MONDO:0010311