DSTYK

dual serine/threonine and tyrosine protein kinase
OMIM: 612666, Gene2Phenotype

12 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 12 panels
Green DSTYK in Unexplained kidney failure in young people Level 3: Disorders of function Level 2: Renal and urinary tract disorders Version 1.124	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes {Congenital anomalies of kidney and urinary tract, susceptibility to} 610805
Red DSTYK in Hereditary spastic paraplegia Level 3: Motor Disorders of the CNS Level 2: Neurology and neurodevelopmental disorders Version 1.316	review	BIALLELIC, autosomal or pseudoautosomal	Sources Other Phenotypes Spastic paraplegia 23, 270750 Tags founder-effect
Amber DSTYK in Childhood onset hereditary spastic paraplegia Level 2: Neurology Version 8.30 Latest signed off version: v8.0 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Amber Yorkshire and North East GLH NHS GMS London North GLH Other Phenotypes Spastic paraplegia 23, 270750 ongenital anomalies of kidney and urinary tract 1, 610805, AD Spastic paraplegia 23, 270750, AR
Amber DSTYK in Adult onset hereditary spastic paraplegia Level 2: Neurology Version 6.7 Latest signed off version: v6.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Amber Yorkshire and North East GLH South West GLH NHS GMS London North GLH Phenotypes Spastic paraplegia 23, 270750, AR Spastic paraplegia 23, 270750 Congenital anomalies of kidney and urinary tract 1, 610805, AD
Green DSTYK in CAKUT Level 3: Structural renal and urinary tract disease Level 2: Renal and urinary tract disorders Version 1.181	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Radboud University Medical Center, Nijmegen Phenotypes Renal hypodysplasia ureteropelvic junction obstruction vesicoureteric reflux CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT, CAKUT1 {Congenital anomalies of kidney and urinary tract, susceptibility to}, 610805
Red DSTYK in Adult onset neurodegenerative disorder Level 2: Neurology Version 8.11 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Yorkshire and North East GLH Expert Review Red Phenotypes Spastic paraplegia 23, 270750 Tags founder-effect
Green DSTYK in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.140 Latest signed off version: v6.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources PAGE DD-Gene2Phenotype Expert Review Green Phenotypes CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT, CAKUT1
Green DSTYK in DDG2P Version 6.424 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources DD-Gene2Phenotype Expert Review Green Phenotypes CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT, CAKUT1 610805 Autosomal Recessive Complicated Spastic Paraparesis SPG23
Red DSTYK in Hereditary neuropathy Level 3: Motor and Sensory Disorders of the PNS Level 2: Neurology and neurodevelopmental disorders Version 1.506	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS London North GLH Phenotypes Spastic paraplegia 23, 270750 Childhood onset spastic paraplegia, prominent skin pigment abnormalities (vitiligo, hyperpigmentation, diffuse lentigines), premature greying of hair, sensory predominant axonal neuropathy (mild).
Red DSTYK in Intellectual disability Level 2: Developmental disorders Version 9.279 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red BRIDGE study SPEED NEURO Tier1 Gene Phenotypes {Congenital anomalies of kidney and urinary tract, susceptibility to}, 610805
Amber DSTYK in Hereditary neuropathy or pain disorder Level 2: Neurology Version 7.36 Latest signed off version: v7.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber London North GLH NHS GMS NHS GMS London North GLH Phenotypes Spastic paraplegia 23, autosomal recessive, OMIM:270750 hereditary spastic paraplegia 23, MONDO:0010046 Tags founder-effect
Green DSTYK in Unexplained young onset end-stage renal disease - additional genes Level 2: Renal Version 1.4 Latest signed off version: v1.1 (30 Apr 2025) Component of the following Super Panels: Unexplained young onset end-stage renal disease	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Phenotypes Congenital anomalies of kidney and urinary tract 1, OMIM:610805