FANCM

Fanconi anemia complementation group M
OMIM: 609644, Gene2Phenotype

19 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 19 panels
Red FANCM in Radial dysplasia Level 3: Dysmorphic disorders Level 2: Dysmorphic and congenital abnormality syndromes Version 1.25	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen UKGTN Eligibility statement prior genetic testing Phenotypes Fanconi Anemia
Amber FANCM in Haematological malignancies for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.19	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Curated sources Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Amber FANCM in Head and neck cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.1	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Expert list Phenotypes Head and neck cancer Tags drug-toxicity
Red FANCM in IUGR and IGF abnormalities Level 3: Growth hormone disorders Level 2: Endocrine disorders Version 1.70	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert review Phenotypes Fanconi Anemia Fanconi anemia, complementation group M, 614087 Fanconi anemia Tags drug-toxicity
Red FANCM in Neurofibromatosis Type 1 Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.33	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Illumina TruGenome Clinical Sequencing Services UKGTN Radboud University Medical Center, Nijmegen Phenotypes Fanconi anemia, complementation group M, 614087 Fanconi Anemia Fanconi Anaemia
Green FANCM in COVID-19 research Level 2: Viral research Version 1.146	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green IUIS Classification December 2019 Phenotypes Bone marrow failure Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage Fanconi Anemia Type M
Green FANCM in Primary ovarian insufficiency Level 3: Gonadal and sex development disorders Level 2: Endocrine disorders Version 1.71	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Literature Phenotypes ?Premature ovarian failure 15, OMIM:618096
Red FANCM in Childhood solid tumours Level 2: Cancer susceptibility Version 5.9 Latest signed off version: v5.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Fanconi anemia, complementation group M, 614087 Fanconi Anemia Fanconi Anaemia
Red FANCM in Limb disorders Level 2: Musculoskeletal Version 7.20 Latest signed off version: v7.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	Not set	Sources Expert Review Red Victorian Clinical Genetics Services Phenotypes Radial Ray abnormality
Red FANCM in Pigmentary skin disorders Level 2: Dermatology Version 4.13 Latest signed off version: v4.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert Review
Red FANCM in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.78 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification December 2019 Phenotypes Bone marrow failure Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage Fanconi Anemia Type M
Red FANCM in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.123	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red UKGTN Expert list Illumina TruGenome Clinical Sequencing Services Phenotypes Fanconi Anemia Fanconi anemia, complementation group M, 614087
Amber FANCM in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.30	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Expert list Phenotypes Fanconi Anemia Tags drug-toxicity
Amber FANCM in Haematological malignancies cancer susceptibility Level 2: Cancer susceptibility Version 4.37 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Curated sources Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar Tags drug-toxicity
Red FANCM in Severe microcephaly Level 2: Neurology Version 8.31 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Red Other Phenotypes Fanconi anemia
Red FANCM in Confirmed Fanconi anaemia or Bloom syndrome Level 2: Haematology Version 2.13 Latest signed off version: v2.5 (1 May 2024)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Yorkshire and North East GLH NHS GMS Wessex and West Midlands GLH Phenotypes Fanconi Anemia 614087Fanconi anemia, complementation group M Fanconi anemia, complementation group M, 614087
Amber FANCM in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.140 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber PAGE DD-Gene2Phenotype Phenotypes FANCM-RELATED FANCONI ANEMIA FANCONI ANEMIA
Green FANCM in DDG2P Version 6.424 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green DD-Gene2Phenotype Phenotypes FANCM-RELATED FANCONI ANEMIA 287713 FANCONI ANEMIA 229154
Red FANCM in Monogenic short stature Level 2: Endocrinology Version 1.31 Latest signed off version: v1.0 (7 Aug 2024)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Phenotypes Fanconi anemia, complementation group M, 614087

FANCM

19 panels

Red FANCM in Radial dysplasia

Sources

Phenotypes

Amber FANCM in Haematological malignancies for rare disease

Sources

Phenotypes

Amber FANCM in Head and neck cancer pertinent cancer susceptibility

Sources

Phenotypes

Tags

Red FANCM in IUGR and IGF abnormalities

Sources

Phenotypes

Tags

Red FANCM in Neurofibromatosis Type 1

Sources

Phenotypes

Green FANCM in COVID-19 research

Sources

Phenotypes

Green FANCM in Primary ovarian insufficiency

Sources

Phenotypes

Red FANCM in Childhood solid tumours

Sources

Phenotypes

Red FANCM in Limb disorders

Sources

Phenotypes

Red FANCM in Pigmentary skin disorders

Sources

Red FANCM in Primary immunodeficiency or monogenic inflammatory bowel disease

Sources

Phenotypes

Red FANCM in Cytopenias and congenital anaemias

Sources

Phenotypes

Amber FANCM in Childhood solid tumours cancer susceptibility

Sources

Phenotypes

Tags

Amber FANCM in Haematological malignancies cancer susceptibility

Sources

Phenotypes

Tags

Red FANCM in Severe microcephaly

Sources

Phenotypes

Red FANCM in Confirmed Fanconi anaemia or Bloom syndrome

Sources

Phenotypes

Amber FANCM in Fetal anomalies

Sources

Phenotypes

Green FANCM in DDG2P

Sources

Phenotypes

Red FANCM in Monogenic short stature

Sources

Phenotypes