FANCM

Fanconi anemia complementation group M
OMIM: 609644, Gene2Phenotype

20 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 20 panels
Red FANCM in Radial dysplasia Level 3: Dysmorphic disorders Level 2: Dysmorphic and congenital abnormality syndromes Version 1.24	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen UKGTN Eligibility statement prior genetic testing Phenotypes Fanconi Anemia
Amber FANCM in Haematological malignancies for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.17	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Curated sources Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Amber FANCM in Head and neck cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.0	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Expert list Phenotypes Head and neck cancer Tags drug-toxicity
Red FANCM in IUGR and IGF abnormalities Level 3: Growth hormone disorders Level 2: Endocrine disorders Version 1.65	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert review Phenotypes Fanconi Anemia Fanconi anemia, complementation group M, 614087 Fanconi anemia Tags drug-toxicity
Red FANCM in Neurofibromatosis Type 1 Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.32	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen UKGTN Phenotypes Fanconi anemia, complementation group M, 614087 Fanconi Anemia Fanconi Anaemia
Green FANCM in COVID-19 research Level 2: Viral research Version 1.142	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green IUIS Classification December 2019 Phenotypes Bone marrow failure Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage Fanconi Anemia Type M
Green FANCM in Primary ovarian insufficiency Level 3: Gonadal and sex development disorders Level 2: Endocrine disorders Version 1.68	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Literature Phenotypes ?Premature ovarian failure 15, OMIM:618096
Red FANCM in Refuted genes Version 0.13	review	BIALLELIC, autosomal or pseudoautosomal	Sources Literature Phenotypes Fanconi anemia, complementation group M, 614087 Fanconi Anemia Fanconi Anaemia
Red FANCM in Childhood solid tumours Level 3: Childhood Tumours Level 2: Tumour syndromes Version 4.18 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Fanconi anemia, complementation group M, 614087 Fanconi Anemia Fanconi Anaemia
Red FANCM in Limb disorders Version 4.21 Latest signed off version: v4.0 (22 Mar 2023) Component of the following Super Panels: Paediatric disorders	review	Not set	Sources Expert Review Red Victorian Clinical Genetics Services Phenotypes Radial Ray abnormality
Red FANCM in Pigmentary skin disorders Version 3.12 Latest signed off version: v3.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Expert Review
Red FANCM in Primary immunodeficiency or monogenic inflammatory bowel disease Version 4.202 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification December 2019 Phenotypes Bone marrow failure Normal to low NK, CNS, skeletal, skin, cardiac, GI, urogenital anomalies, increased chromosomal breakage Fanconi Anemia Type M
Red FANCM in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.118	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red UKGTN Illumina TruGenome Clinical Sequencing Services Expert list Phenotypes Fanconi Anemia Fanconi anemia, complementation group M, 614087
Amber FANCM in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.27	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Expert list Phenotypes Fanconi Anemia Tags drug-toxicity
Amber FANCM in Haematological malignancies cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 4.4 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Curated sources Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar Tags drug-toxicity
Red FANCM in Severe microcephaly Level 3: DNA repair disorders Level 2: Dysmorphic and congenital abnormality syndromes Version 4.82 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Red Other Phenotypes Fanconi anemia
Red FANCM in Confirmed Fanconi anaemia or Bloom syndrome Version 2.4 Latest signed off version: v2.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Yorkshire and North East GLH NHS GMS Wessex and West Midlands GLH Phenotypes Fanconi Anemia 614087Fanconi anemia, complementation group M Fanconi anemia, complementation group M, 614087
Amber FANCM in Fetal anomalies Version 3.164 Latest signed off version: v3.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber PAGE DD-Gene2Phenotype Phenotypes FANCM-RELATED FANCONI ANEMIA FANCONI ANEMIA
Green FANCM in DDG2P Version 3.88 Latest signed off version: v3.1 (22 Mar 2023) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green DD-Gene2Phenotype Phenotypes FANCM-RELATED FANCONI ANEMIA 287713 FANCONI ANEMIA 229154
Red FANCM in Growth failure in early childhood Version 3.94 Latest signed off version: v3.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Phenotypes Fanconi anemia, complementation group M, 614087

FANCM

20 panels

Red FANCM in Radial dysplasia

Sources

Phenotypes

Amber FANCM in Haematological malignancies for rare disease

Sources

Phenotypes

Amber FANCM in Head and neck cancer pertinent cancer susceptibility

Sources

Phenotypes

Tags

Red FANCM in IUGR and IGF abnormalities

Sources

Phenotypes

Tags

Red FANCM in Neurofibromatosis Type 1

Sources

Phenotypes

Green FANCM in COVID-19 research

Sources

Phenotypes

Green FANCM in Primary ovarian insufficiency

Sources

Phenotypes

Red FANCM in Refuted genes

Sources

Phenotypes

Red FANCM in Childhood solid tumours

Sources

Phenotypes

Red FANCM in Limb disorders

Sources

Phenotypes

Red FANCM in Pigmentary skin disorders

Sources

Red FANCM in Primary immunodeficiency or monogenic inflammatory bowel disease

Sources

Phenotypes

Red FANCM in Cytopenias and congenital anaemias

Sources

Phenotypes

Amber FANCM in Childhood solid tumours cancer susceptibility

Sources

Phenotypes

Tags

Amber FANCM in Haematological malignancies cancer susceptibility

Sources

Phenotypes

Tags

Red FANCM in Severe microcephaly

Sources

Phenotypes

Red FANCM in Confirmed Fanconi anaemia or Bloom syndrome

Sources

Phenotypes

Amber FANCM in Fetal anomalies

Sources

Phenotypes

Green FANCM in DDG2P

Sources

Phenotypes

Red FANCM in Growth failure in early childhood

Sources

Phenotypes