FGB

fibrinogen beta chain
OMIM: 134830, Gene2Phenotype

4 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 4 panels
Green FGB in Inherited bleeding disorders Level 3: Haemostasis disorders Level 2: Haematological and immunological disorders Version 1.178	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Radboud University Medical Center, Nijmegen Other Expert Review Green BRIDGE Study Tier 1 Gene Phenotypes Fibrinogen deficiency Dysfibrinogenemia,congenital,616004 dysbetafibrinogenemia with thrombosis Thrombophilia in association with congenital dysfibrinogenemia
Green FGB in Thrombophilia with a likely monogenic cause Version 2.5 Latest signed off version: v2.2 (22 Mar 2023)	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes Afibrinogenemia, congenital, OMIM:202400 Hypofibrinogenemia, congenital, OMIM:202400 Dysfibrinogenemia, congenital, OMIM:616004 Thrombophilia, MONDO:0002305
Green FGB in Bleeding and platelet disorders Version 3.10 Latest signed off version: v3.0 (22 Mar 2023)	review	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes 202400 Afibrinogenemia, congenital 202400 Afibrinogenemia, congenital, Hypofibrinogenemia, congenital, 616004 Dysfibrinogenemia, congenital 616004 Dysfibrinogenemia, congenital 202400 Hypofibrinogenemia, congenital 202400 Afibrinogenemia, congenital, Hypofibrinogenemia, congenital
Green FGB in Severe Paediatric Disorders Version 1.184	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes Dysfibrinogenemia, congenital, 616004 Afibrinogenemia, congenital, 202400 Hypofibrinogenemia, congenital, 202400