FOXN1

forkhead box N1
OMIM: 600838, Gene2Phenotype

6 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 6 panels
No list FOXN1 in Familial cicatricial alopecia Level 3: Skin adnexa disorders Level 2: Dermatological disorders Version 1.6	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Removed Other UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes T-cell immunodeficiency, congenital alopecia, and nail dystrophy, OMIM:601705 Tags curated_removed
Green FOXN1 in COVID-19 research Level 2: Viral research Version 1.147	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources IUIS Classification December 2024 IUIS Classification February 2018 SCID v1.6 London North GLH NHS GMS GRID V2.0 Victorian Clinical Genetics Services North West GLH ESID Registry 20171117 Expert Review Green NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services Expert Review Green ESID Registry 20171117 GRID V2.0 SCID v1.6 Phenotypes T-cell immunodeficiency, congenital alopecia, and nail dystrophy, OMIM:601705 (AR) T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant, OMIM:618806 (AD) T-B+ SCID Severe infections, abnormal thymic epithelium, immunodeficiency, congenital alopecia, nail dystrophy, neural tube defect Combined immunodeficiencies with associated or syndromic features
Green FOXN1 in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.99 Latest signed off version: v8.0 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green Other NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 SCID v1.6 Phenotypes T-cell immunodeficiency, congenital alopecia, and nail dystrophy, OMIM:601705 (AR) T-cell lymphopenia, infantile, with or without nail dystrophy, autosomal dominant, OMIM:618806 (AD) T-B+ SCID Severe infections, abnormal thymic epithelium, immunodeficiency, congenital alopecia, nail dystrophy, neural tube defect Combined immunodeficiencies with associated or syndromic features Tags founder-effect
Red FOXN1 in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.185 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red PAGE DD-Gene2Phenotype Phenotypes ALOPECIA AND T-CELL IMMUNODEFICIENCY
Green FOXN1 in DDG2P Version 6.447 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources DD-Gene2Phenotype Expert Review Green Phenotypes ALOPECIA AND T-CELL IMMUNODEFICIENCY 601705
Red FOXN1 in Intellectual disability Level 2: Developmental disorders Version 9.370 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red BRIDGE study SPEED NEURO Tier1 Gene Phenotypes T-cell immunodeficiency, congenital alopecia, and nail dystrophy, 601705