Familial cicatricial alopecia

Gene: FOXN1

No list

FOXN1 (forkhead box N1)
EnsemblGeneIds (GRCh38): ENSG00000109101
EnsemblGeneIds (GRCh37): ENSG00000109101
OMIM: 600838, Gene2Phenotype
FOXN1 is in 7 panels

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Grey: congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel.
Created: 10 Jul 2017, 2:59 p.m.
Comment on list classification: Updated rating from Green to Red: Green rating came from number of sources, but alopecia phenotype is not specific to scarring/cicatricial subtype.
Created: 3 Jul 2017, 2:12 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Removed
  • Other
  • UKGTN
  • Illumina TruGenome Clinical Sequencing Services
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • T-cell immunodeficiency, congenital alopecia, and nail dystrophy, 601705
  • Alopecia and T-Cell Immunodeficiency
  • congenital severe combined immunodeficiency associated with alopecia
Tags
curated_removed
OMIM
600838
Clinvar variants
Variants in FOXN1
Penetrance
Complete
Panels with this gene

History Filter Activity

26 Feb 2021, Gel status: 0

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag curated_removed tag was added to gene: FOXN1.

20 Jul 2017, Gel status: 0

panel promoted to version 1

Rebecca Foulger (Genomics England curator)

20 July 2017: Reviews from Prof. John McGrath were assessed, and panel was revised largely to reflect his expert review. Demoted FOXN1 and GJA1 to grey because the congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel. For most of the red genes, there is only very minor (often indirect) evidence to support a link to cicatricial alopecia, but they remain on the panel, for now, for completeness.

10 Jul 2017, Gel status: 0

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been removed from the panel.

3 Jul 2017, Gel status: 1

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Red List (Low Evidence).

22 Nov 2016, Gel status: 3

Added New Source

Rebecca Foulger (Genomics England curator)

FOXN1 was added to Familial cicatricial alopeciapanel. Source: Other

22 Nov 2016, Gel status: 3

Added New Source

Rebecca Foulger (Genomics England curator)

FOXN1 was added to Familial cicatricial alopeciapanel. Source: UKGTN

22 Nov 2016, Gel status: 2

Set Mode of Inheritance, Added New Source

Rebecca Foulger (Genomics England curator)

FOXN1 was added to Familial cicatricial alopeciapanel. Source: Illumina TruGenome Clinical Sequencing Services Model of inheritance for gene FOXN1 was set to BIALLELIC, autosomal or pseudoautosomal

22 Nov 2016, Gel status: 0

Created

Rebecca Foulger (Genomics England curator)

FOXN1 was created by rfoulger

22 Nov 2016, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

FOXN1 was added to Familial cicatricial alopeciapanel. Sources: Radboud University Medical Center, Nijmegen