Familial cicatricial alopecia
Gene: FOXN1Comment on list classification: Updated rating from Red to Grey: congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel.Created: 10 Jul 2017, 2:59 p.m.
Comment on list classification: Updated rating from Green to Red: Green rating came from number of sources, but alopecia phenotype is not specific to scarring/cicatricial subtype.Created: 3 Jul 2017, 2:12 p.m.
Phenotypes for gene: FOXN1 were changed from T-cell immunodeficiency, congenital alopecia, and nail dystrophy, 601705; Alopecia and T-Cell Immunodeficiency; congenital severe combined immunodeficiency associated with alopecia to T-cell immunodeficiency, congenital alopecia, and nail dystrophy, OMIM:601705
Tag curated_removed tag was added to gene: FOXN1.
20 July 2017: Reviews from Prof. John McGrath were assessed, and panel was revised largely to reflect his expert review. Demoted FOXN1 and GJA1 to grey because the congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel. For most of the red genes, there is only very minor (often indirect) evidence to support a link to cicatricial alopecia, but they remain on the panel, for now, for completeness.
This gene has been removed from the panel.
This gene has been classified as Red List (Low Evidence).
FOXN1 was added to Familial cicatricial alopeciapanel. Source: Other
FOXN1 was added to Familial cicatricial alopeciapanel. Source: UKGTN
FOXN1 was added to Familial cicatricial alopeciapanel. Source: Illumina TruGenome Clinical Sequencing Services Model of inheritance for gene FOXN1 was set to BIALLELIC, autosomal or pseudoautosomal
FOXN1 was created by rfoulger
FOXN1 was added to Familial cicatricial alopeciapanel. Sources: Radboud University Medical Center, Nijmegen