Familial cicatricial alopeciaGene: PPARG
Comment on list classification: Kept rating as Red: insufficient direct evidence to link PPARG to cicatricial (scarring) alopecia.
Created: 13 Jul 2017, 2:50 p.m.
PMID:19052558 (Karnik et al., 2009, reviewed by PMID:19369934) report that targeted deletion of PPAR-gamma in follicular stem cells in mice, causes a skin and hair phenotype that emulates cicatricial (scarring) alopecia.
Created: 13 Jul 2017, 2:49 p.m.
20 July 2017: Reviews from Prof. John McGrath were assessed, and panel was revised largely to reflect his expert review. Demoted FOXN1 and GJA1 to grey because the congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel. For most of the red genes, there is only very minor (often indirect) evidence to support a link to cicatricial alopecia, but they remain on the panel, for now, for completeness.
This gene has been classified as Red List (Low Evidence).
Publications for PPARG were set to 19369934; 19052558
PPARG was created by rfoulger
PPARG was added to Familial cicatricial alopeciapanel. Sources: Literature