Familial cicatricial alopecia


Amber List (moderate evidence)

HLA-DRA (major histocompatibility complex, class II, DR alpha)
EnsemblGeneIds (GRCh38): ENSG00000204287
EnsemblGeneIds (GRCh37): ENSG00000204287
OMIM: 142860, Gene2Phenotype
HLA-DRA is in 3 panels

2 reviews

John McGrath (KCL)

I don't know

This has been associated with a form of scarring alopecia in one Indian family but with no fine mapping of the locus. Amber because of the single family reports and only component features of other syndromes.
Created: 22 Jun 2017, 2:59 p.m.

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber to match expert review.
Created: 13 Jul 2017, 1:30 p.m.
Orphanet used as source for HLA-DRA and Graham Little syndrome- a subtype of lichen planopilaris characterized by symptoms including progressive cicatricial (scarring) alopecia.
Created: 22 Nov 2016, 5:12 p.m.


Mode of Inheritance
  • Expert Review Amber
  • Other
  • Graham Little-Piccardi-Lassueur syndrome
  • Graham Little syndrome
  • lichen planopilaris
  • progressive cicatricial (scarring) alopecia
Clinvar variants
Variants in HLA-DRA
Panels with this gene

History Filter Activity

20 Jul 2017, Gel status: 2

panel promoted to version 1

Rebecca Foulger (Genomics England curator)

20 July 2017: Reviews from Prof. John McGrath were assessed, and panel was revised largely to reflect his expert review. Demoted FOXN1 and GJA1 to grey because the congenital alopecia phenotype is too broad for this cicatricial (scarring) alopecia panel. For most of the red genes, there is only very minor (often indirect) evidence to support a link to cicatricial alopecia, but they remain on the panel, for now, for completeness.

13 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Amber List (Moderate Evidence).

22 Nov 2016, Gel status: 0


Rebecca Foulger (Genomics England curator)

HLA-DRA was created by rfoulger

22 Nov 2016, Gel status: 0

Added New Source

Rebecca Foulger (Genomics England curator)

HLA-DRA was added to Familial cicatricial alopeciapanel. Sources: Other