PanelApp
  1. Genes and Genomic Entities
  2. GREM1

GREM1

gremlin 1, DAN family BMP antagonist
OMIM: 603054, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels

Red GREM1 in VACTERL-like phenotypes

Level 3: Limb disorders
Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.29

review Not set
Sources
  • Emory Genetics Laboratory

Red GREM1 in GI tract tumours

Level 3: GI tract
Level 2: Tumour syndromes
Version 1.18

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • NHS GMS
  • UKGTN
  • Radboud University Medical Center, Nijmegen
  • Literature
  • Expert Review Red
Phenotypes
  • {Colorectal cancer, increased risk, association with}(Peters (2012) Hum Genet 131,217)
  • Oligosyndactyly of the hands, Cenani-Linz-like (Dimitrov (2010) J Med Genet 47,569)
  • Mixed polyposis syndrome (Jaeger (2012) Nat Genet 44,699)
  • Polyposis Syndrome, Hereditary Mixed, 1
  • Hereditary Mixed Polyposis Syndrome
Tags
  • structural-variant

Red GREM1 in Limb disorders


Version 2.39
Signed off v.2.2 on 13 Feb 2020

Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • Literature
    Tags
    • watchlist
    • structural-variant

    Amber GREM1 in Inherited polyposis


    Version 1.24
    Signed off v.1.2 on 4 Mar 2020

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • NHS GMS
    Phenotypes
    • Hereditary Mixed Polyposis Syndrome
    • Oligosyndactyly of the hands, Cenani-Linz-like (Dimitrov (2010) J Med Genet 47,569)
    • Polyposis Syndrome, Hereditary Mixed, 1
    • Mixed polyposis syndrome (Jaeger (2012) Nat Genet 44,699)
    • {Colorectal cancer, increased risk, association with}(Peters (2012) Hum Genet 131,217)

    Red GREM1 in Unexplained kidney failure in young people

    Level 3: Disorders of function
    Level 2: Renal and urinary tract disorders
    Version 1.92

    Component of the following Super Panels:

  • Renal superpanel - broad

    		•  review Not set
    Sources
    • Expert Review Red
    • Expert list

    Red GREM1 in Skeletal dysplasia

    Level 3: Skeletal dysplasias
    Level 2: Skeletal disorders
    Version 2.87
    Signed off v.2.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review Unknown
    Sources
    • Expert Review Red
    • Emory Genetics Laboratory
    • Expert list
    • UKGTN

    Red GREM1 in CAKUT

    Level 3: Structural renal and urinary tract disease
    Level 2: Renal and urinary tract disorders
    Version 1.160

    Component of the following Super Panels:

  • Renal superpanel - broad
  • Renal superpanel - narrow

    		•  review Not set
    Sources
    • Expert Review Red
    • Expert list

    Red GREM1 in Unexplained paediatric onset end-stage renal disease


    Version 1.16
    Signed off v.1.2 on 4 Mar 2020

    Component of the following Super Panels:

  • Renal superpanel - broad

    		•  review Unknown
    Sources
    • Expert Review Red