1. Genes and Genomic Entities
  2. GREM1

GREM1

gremlin 1, DAN family BMP antagonist
OMIM: 603054, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels
Red GREM1 in VACTERL-like phenotypes

Level 3: Limb disorders
Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.35

review Not set
Sources
  • Emory Genetics Laboratory
Red GREM1 in GI tract tumours

Level 3: GI tract
Level 2: Tumour syndromes
Version 1.27

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • NHS GMS
  • UKGTN
  • Radboud University Medical Center, Nijmegen
  • Literature
  • Expert Review Red
Phenotypes
  • {Colorectal cancer, increased risk, association with}(Peters (2012) Hum Genet 131,217)
  • Oligosyndactyly of the hands, Cenani-Linz-like (Dimitrov (2010) J Med Genet 47,569)
  • Mixed polyposis syndrome (Jaeger (2012) Nat Genet 44,699)
  • Polyposis Syndrome, Hereditary Mixed, 1
  • Hereditary Mixed Polyposis Syndrome
Tags
  • structural-variant
Red GREM1 in Limb disorders


Level 2: Musculoskeletal
Version 7.17
Latest signed off version: v7.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • Literature
    Tags
    • watchlist
    • structural-variant
    Green GREM1 in Inherited polyposis and early onset colorectal cancer - germline testing


    Level 2: Inherited cancer
    Version 3.11
    Latest signed off version: v3.0 (7 Aug 2024)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Hereditary mixed polyposis syndrome, MONDO:0011023
    Tags
    • gene-checked
    • regulatory-region
    Red GREM1 in Unexplained kidney failure in young people

    Level 3: Disorders of function
    Level 2: Renal and urinary tract disorders
    Version 1.124

    		review Not set
    Sources
    • Expert Review Red
    • Expert list
    Red GREM1 in Skeletal dysplasia


    Level 2: Musculoskeletal
    Version 8.33
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review Unknown
    Sources
    • Expert Review Red
    • Emory Genetics Laboratory
    • Expert list
    • UKGTN
    Red GREM1 in CAKUT

    Level 3: Structural renal and urinary tract disease
    Level 2: Renal and urinary tract disorders
    Version 1.181

    		review Not set
    Sources
    • Expert Review Red
    • Expert list
    Red GREM1 in Unexplained young onset end-stage renal disease - additional genes


    Level 2: Renal
    Version 1.4
    Latest signed off version: v1.1 (30 Apr 2025)

    Component of the following Super Panels:

  • Unexplained young onset end-stage renal disease

    		•  review Unknown
    Sources
    • Expert Review Red