IGF2

insulin like growth factor 2
OMIM: 147470, Gene2Phenotype

8 panels

Panel Reviews Mode of inheritance Details
8 panels
Green IGF2 in Silver Russell syndrome

Level 3: Growth restriction
Level 2: Growth disorders
Version 1.14

review MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)
Sources
  • Expert Review Green
  • Expert Review Green
  • UKGTN
Phenotypes
  • Silver Russell syndrome, 180860
Red IGF2 in IUGR and IGF abnormalities

Level 3: Growth hormone disorders
Level 2: Endocrine disorders
Version 1.70

review MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Sources
  • Expert Review Red
  • Literature
  • Expert Review
Phenotypes
  • Pre- and post-natal growth failure
  • Silver-Russell phenptype
  • IUGR
Tags
  • watchlist
Red IGF2 in Childhood solid tumours


Level 2: Cancer susceptibility
Version 5.9
Latest signed off version: v5.0 (30 Apr 2025)

review Not set
Sources
  • Expert Review Red
  • UKGTN
Phenotypes
  • Beckwith-Wiedemann Syndrome
Red IGF2 in Beckwith-Wiedemann syndrome (BWS) and other congenital overgrowth disorders

Level 3: Beckwith-Wiedemann syndrome (BWS) and other congenital overgrowth disorders
Level 2: Growth disorders
Version 1.121

review MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Sources
  • Expert Review Red
  • UKGTN
Phenotypes
  • Beckwith-Wiedemann Syndrome
Green IGF2 in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 6.140
Latest signed off version: v6.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Sources
  • PAGE DD-Gene2Phenotype
  • Expert Review Green
Phenotypes
  • CHROMOSOME 11P15.5-RELATED RUSSELL-SILVER SYNDROME
  • BECKWITH-WIEDEMANN SYNDROME
Green IGF2 in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • BECKWITH-WIEDEMANN SYNDROME 130650
    • CHROMOSOME 11P15.5-RELATED RUSSELL-SILVER SYNDROME 180860
    Red IGF2 in Intellectual disability


    Level 2: Developmental disorders
    Version 9.285
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review Other - please specify in evaluation comments
    Sources
    • Expert Review Red
    • BRIDGE study SPEED NEURO Tier1 Gene
    Phenotypes
    • Beckwith-Wiedemann Syndrome
    • Chromosome 11p15.5-Related Russell-Silver Syndrome
    Green IGF2 in Monogenic short stature


    Level 2: Endocrinology
    Version 1.31
    Latest signed off version: v1.0 (7 Aug 2024)

    review MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Silver-Russell syndrome 3, OMIM:616489