IL12B

Red IL12B in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.75

Sources

• Other

Phenotypes

• Crohn disease

Green IL12B in COVID-19 research

Level 2: Viral research
Version 1.141

Sources

• IUIS Classification February 2018
• London North GLH
• NHS GMS
• GRID V2.0
• Victorian Clinical Genetics Services
• North West GLH
• ESID Registry 20171117
• Expert Review Green
• NHS GMS
• North West GLH
• London North GLH
• Expert Review Green
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• ESID Registry 20171117
• GRID V2.0

Phenotypes

• Susceptibility to mycobacteria and Salmonella
• Immunodeficiency 29, mycobacteriosis, 614890
• Defects with susceptibility to mycobacterial infection (MSMD)
• Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency
• Defects in Intrinsic and Innate Immunity

Green IL12B in Primary immunodeficiency or monogenic inflammatory bowel disease

Version 4.201
Latest signed off version: v4.0 (22 Mar 2023)

Sources

• NHS GMS
• North West GLH
• London North GLH
• Expert Review Green
• IUIS Classification February 2018
• Victorian Clinical Genetics Services
• ESID Registry 20171117
• GRID V2.0

Phenotypes

• Immunodeficiency 29, mycobacteriosis, 614890
• Defects with susceptibility to mycobacterial infection (MSMD)
• Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency
• Susceptibility to mycobacteria and Salmonella
• Defects in Intrinsic and Innate Immunity

Green IL12B in Severe Paediatric Disorders

Version 1.184

Sources

• Next Generation Children Project
• Expert Review Green
• Expert list

Phenotypes

• Immunodeficiency 29, mycobacteriosis, 614890