MED12

mediator complex subunit 12
OMIM: 300188, Gene2Phenotype

12 panels

Panel Reviews Mode of inheritance Details
12 panels
Red MED12 in Familial Hirschsprung Disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.11

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Hirschsprung disease
  • HSCR
Red MED12 in Thoracic aortic aneurysm or dissection (GMS)


Level 2: Cardiology
Version 4.5
Latest signed off version: v4.0 (30 Apr 2025)

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Red
  • NHS GMS
  • South West GLH
  • London South GLH
  • South West GLH
  • London South GLH
Phenotypes
  • Lujan-Fryns syndrome, OMIM:309520
  • Marfan Syndrome, Thoracic Aortic Aneurysm & Dissection (TAAD), and Related Disorders
Red MED12 in Thoracic aortic aneurysm or dissection

Level 3: Connective tissue disorders and aortopathies
Level 2: Cardiovascular disorders
Version 1.129

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Red
  • South West GLH
  • London South GLH
  • Emory Genetics Laboratory
Phenotypes
  • Lujan-Fryns syndrome, OMIM:309520
  • Marfan Syndrome, Thoracic Aortic Aneurysm & Dissection (TAAD), and Related Disorders
Green MED12 in Arthrogryposis


Level 2: Neurology
Version 9.24
Latest signed off version: v9.0 (30 Apr 2025)

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • MED12-related disorders
  • Opitz-Kaveggia syndrome, OMIM:305450
  • Ohdo syndrome, X-linked, OMIM:300895
  • Lujan-Fryns syndrome, OMIM:309520
Green MED12 in Non-syndromic familial congenital anorectal malformations

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.14

review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • anorectal malformation
  • Opitz-Kaveggia syndrome 305450
  • FG SYNDROME 1
  • FG SYNDROME
Tags
  • Skewed X-inactivation
No list MED12 in Ehlers Danlos syndrome with a likely monogenic cause


Level 2: Musculoskeletal
Version 4.6
Latest signed off version: v4.0 (30 Apr 2025)

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Removed
  • Emory Genetics Laboratory
Phenotypes
  • Lujan-Fryns syndrome, 309520
  • Ohdo syndrome, X-linked, 300895
  • Opitz-Kaveggia syndrome, 305450
Tags
  • curated_removed
Green MED12 in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 6.140
Latest signed off version: v6.0 (30 Apr 2025)

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • PAGE DD-Gene2Phenotype
  • Expert Review Green
Phenotypes
  • LUJAN-FRYNS SYNDROME
  • OPITZ-KAVEGGIA SYNDROME
Tags
  • to_be_confirmed_NHSE
  • Skewed X-inactivation
Green MED12 in DDG2P


Version 6.424
Latest signed off version: v6.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • OPITZ-KAVEGGIA SYNDROME 305450
    • LUJAN-FRYNS SYNDROME 309520
    Green MED12 in Clefting


    Level 2: Musculoskeletal
    Version 6.20
    Latest signed off version: v6.5 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • NHS GMS
    Phenotypes
    • Hardikar syndrome, OMIM:612726
    • cholestasis-pigmentary retinopathy-cleft palate syndrome, MONDO:0012997
    Tags
    • Skewed X-inactivation
    Green MED12 in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 8.125
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Wessex and West Midlands GLH
    • NHS GMS
    • Victorian Clinical Genetics Services
    Phenotypes
    • Lujan-Fryns syndrome, 309520
    • Opitz-Kaveggia syndrome, 305450
    Tags
    • Skewed X-inactivation
    Green MED12 in Intellectual disability


    Level 2: Developmental disorders
    Version 9.285
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Victorian Clinical Genetics Services
    • Expert Review Green
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    Phenotypes
    • Opitz-Kaveggia syndrome, 305450
    • Lujan-Fryns syndrome, 309520
    • Ohdo syndrome, X-linked, 300895
    • OPITZ-KAVEGGIA SYNDROME (OKS)
    Tags
    • Skewed X-inactivation
    Green MED12 in Retinal disorders


    Level 2: Ophthalmology
    Version 8.86
    Latest signed off version: v8.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Hardikar syndrome, OMIM:612726
    • cholestasis-pigmentary retinopathy-cleft palate syndrome, MONDO:0012997
    Tags
    • Skewed X-inactivation