Thoracic aortic aneurysm or dissection (GMS) (Version 3.11)

The latest signed off version for the GMS is v3.0. The current version, shown here, may differ from the signed-off version.

Description

This panel is used as a virtual panel to analyse genome or exome data in the NHS Genomic Medicine Service; the panel will routinely be applied for clinical indication 'R125 Thoracic aortic aneurysm or dissection' but can also be used as part of the analysis for a broader clinical presentation, where relevant.

Further information on the testing criteria and any overlapping clinical indications can be found within (https://www.england.nhs.uk/publication/national-genomic-test-directories/) under 'R125 Thoracic aortic aneurysm or dissection'.

A version of this panel has been signed off under NHS Genomic Medicine Service governance (see 'Latest signed off version' in the panel header information).

This panel will continue to be curated based on external reviews and Genomics England curation. New changes will be reflected in an increase to the minor version of the panel and details of these can be viewed in the 'Panel Activity' page. Periodically, these changes will be reviewed by a NHS Genomic Medicine Service evaluation process. The content that is agreed for the GMS panels will be reflected in an updated signed off version number.

CNVs, STRs and genes encoded by the mitochondrial genome may not be routinely included in the analysis where the panel is NOT delivered by WGS. Please contact your Genomic Laboratory Hub for information regarding specific queries.

Some of the genes in this panel cause conditions that typically present in adulthood. Please consider this when applying the panel.

Panel Activity

27 reviewers

Ellen McDonagh (Genomics England Curator)

Group: Other
Workplace: Other
Bill Newman (Manchester Centre for Genomic Medicine)

Group: other
Workplace: other
Tracy Lester (Genetics laboratory, Oxford UK)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Helen Savage (Congenica Ltd)

Group: Other biotech or pharmaceutical
Workplace: Other clinical service
Matina Prapa (Genomics England Curator)

Group: GeCIP domain
Workplace: Other
Nick Camm (NHS)

Group: Other NHS organisation
Workplace: NHS diagnostic lab
Kate Thomson (Oxford University Hospitals Foundation Trust)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
David Parry (University of Edinburgh)

Group: GeCIP domain
Workplace: Research lab
Caroline Wright (Genomics England Curator)

Group: Other
Workplace: Genomics England
krishna chatterjee (Institute of Metabolic Science, University of Cambridge)

Group: GeCIP domain
Workplace: NHS clinical service
Rebecca Foulger (Genomics England curator)

Group: Other
Workplace: Other
Louise Daugherty (Genomics England Curator)

Group: Other
Workplace: Other
Helen Brittain (Genomics England Curator)

Group: Other
Workplace: Other
Matthew Edwards (Clinical Genetics & Genomics Lab, Royal Brompton & Harefield NHS Trust)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Eleanor Williams (Genomics England Curator)

Group: Other
Workplace: Other
Ataf Sabir (Birmingham Women's Hospital)

Group: NHS Genomic Medicine Centre
Workplace: NHS clinical service
Zornitza Stark (Australian Genomics)

Group: Other
Workplace: Other clinical service
Anna de Burca (Genomics England Curator)

Group: NHS Genomic Medicine Centre
Workplace: NHS clinical service
Chris Buxton (North Bristol NHS Trust)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Ivone Leong (Genomics England Curator)

Group: Other
Workplace: Other
Simon Thomas (Wessex)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
James Eden (Manchester)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Alison Callaway (Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Rebecca Whittington (South West GLH)

Group: NHS Genomic Medicine Centre
Workplace: NHS diagnostic lab
Arina Puzriakova (Genomics England Curator)

Group: Other
Workplace: Other
Achchuthan Shanmugasundram (Genomics England Curator)

Group: Other
Workplace: Other
Andrew Mumford (University of Bristol)

Group: GeCIP domain
Workplace: Research lab

70 Entities

70 reviewed, 33 green

List	Entity	Reviews	Mode of inheritance	Details
Filter Entities 70 Entitiess
Green Green List (high evidence)	ABL1	6 reviews 2 green 1 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Literature South West GLH Phenotypes Failure to thrive in infancy (HP:0001531) Generalized joint laxity (HP:0002761) Ascending aortic dilation (HP:0004970) Congenital finger flexion contractures (HP:0005879) Hypospadias (HP:0000047) Pectus excavatum (HP:0000767) Congenital heart defects and skeletal malformations syndrome, 617602 Scoliosis (HP:0002650) Congenital septal defect (HP:0004760) Tags
Green Green List (high evidence)	ACTA2	8 reviews 7 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Aortic aneurysm, familial thoracic 6, 611788 Aortic aneurysm, familial thoracic 6 (611788) Thoracic aortic aneurysm and dissection Multisystemic smooth muscle dysfunction syndrome, 613834 Moyamoya disease 5 (614042) Thoracic Aortic Aneurysms and Aortic Dissections Multisystemic smooth muscle dysfunction syndrome (613834) Moyamoya disease 5, 614042 Isolated familial thoracic aortic aneurysms and dissection Tags
Green Green List (high evidence)	ASPH	3 reviews 1 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Literature NHS GMS Phenotypes Traboulsi syndrome, OMIM:601552 facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome, MONDO:0011106 Tags
Green Green List (high evidence)	BGN	6 reviews 4 green	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes X-linked syndromic TAAD syndromic thoracic aortic aneurysm and dissection Tags
Green Green List (high evidence)	CBS	8 reviews 3 green 2 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green South West GLH Phenotypes Marfan syndrome Homocystinuria, B6-responsive and nonresponsive types, 236200 Tags
Green Green List (high evidence)	COL3A1	8 reviews 7 green	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Ehlers-Danlos syndrome, type IV, 130050 Loeys-Dietz syndrome Ehlers-Danlos syndrome, vascular type (130050) Tags
Green Green List (high evidence)	COL5A1	10 reviews 6 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Ehlers-Danlos syndrome, classic type, OMIM:130000 Fibromuscular dysplasia, multifocal, OMIM:619329 Tags
Green Green List (high evidence)	COL5A2	9 reviews 6 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Ehlers-Danlos syndrome, classic type, 130000 multisystemic smooth muscle dysfunction syndrome Tags
Green Green List (high evidence)	EFEMP2	8 reviews 6 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Cutis laxa, autosomal recessive, type IB, 614437 aortic aneurysm Tags
Green Green List (high evidence)	ELN	9 reviews 3 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes Supravalvar aortic stenosis, 185500 Cutis laxa, autosomal dominant, 123700 Tags
Green Green List (high evidence)	FBLN5	8 reviews 3 green	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green NHS GMS South West GLH Phenotypes ?Cutis laxa, autosomal dominant 2, OMIM:614434 Cutis laxa, autosomal recessive, type IA, OMIM:219100 Tags
Green Green List (high evidence)	FBN1	9 reviews 8 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Weill-Marchesani syndrome 2, dominant, (608328) Marfan syndrome (154700) Ectopia lentis, familial (129600) Marfan lipodystrophy syndrome (616914) MASS syndrome (604308) Stiff skin syndrome (184900) Geleophysic dysplasia 2 (614185) Marfan Syndrome Aortic aneurysm, ascending, and dissection ongenital contracturalarachnodactyly Acromicric dysplasia (102370) Tags
Green Green List (high evidence)	FBN2	9 reviews 6 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes Congenital Contractural Arachnodactyly Contractural arachnodactyly, congenital, 121050 Tags
Green Green List (high evidence)	FKBP14	8 reviews 3 green 1 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green NHS GMS South West GLH Phenotypes Ehlers-Danlos syndrome, kyphoscoliotic type, 2 614557 Tags
Green Green List (high evidence)	FLNA	9 reviews 5 green	X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)	Sources Expert Review Green London South GLH South West GLH Phenotypes Cardiac valvular dysplasia, X-linked, OMIM:314400 Heterotopia, periventricular, 1, OMIM:300049 Tags
Green Green List (high evidence)	IPO8	3 reviews 2 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Literature NHS GMS Phenotypes Loeys-Dietz syndrome-like cardiovascular, neurologic, skeletal and immunologic abnormalities Tags
Green Green List (high evidence)	LOX	7 reviews 4 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Aortic aneurysm, familial thoracic 10, 617168 aortic aneurysm Tags
Green Green List (high evidence)	MFAP5	8 reviews 1 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes Aortic aneurysm, familial thoracic 9, 616166 Tags
Green Green List (high evidence)	MYH11	9 reviews 8 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Aortic aneurysm, familial thoracic 4, 132900 Aortic aneurysm, familial thoracic 4 (132900) Tags
Green Green List (high evidence)	MYLK	7 reviews 6 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Aortic aneurysm, familial thoracic 7, OMIM:613780 Tags
Green Green List (high evidence)	NOTCH1	9 reviews 5 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Aortic valve disease 1, 109730 Tags
Green Green List (high evidence)	PLOD1	8 reviews 4 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes kyphoscoliotic EDS Ehlers-Danlos syndrome, type VI, 225400 Tags
Green Green List (high evidence)	PRKG1	7 reviews 5 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH NHS GMS South West GLH Phenotypes Aortic aneurysm, familial thoracic 8, 615436 Tags
Green Green List (high evidence)	SKI	7 reviews 6 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Shprintzen-Goldberg Craniosynostosis Syndrome, 182212 Shprintzen-Goldberg syndrome (182212) Marfan Syndrome, Thoracic Aortic Aneurysm & Dissection (TAAD), and Related Disorders Tags
Green Green List (high evidence)	SLC2A10	9 reviews 7 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green London South GLH South West GLH Phenotypes Arterial tortuosity syndrome, 208050 Marfan Syndrome, Thoracic Aortic Aneurysm & Dissection (TAAD), and Related Disorders Tags
Green Green List (high evidence)	SMAD2	8 reviews 4 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes arterial aneurysms and dissections Tags
Green Green List (high evidence)	SMAD3	9 reviews 7 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Loeys Dietz syndrome, type 3 (613795) Loeys Dietz syndrome, type 3, 613795 Tags
Green Green List (high evidence)	SMAD4	9 reviews 3 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, 175050 Tags
Green Green List (high evidence)	SMAD6	4 reviews 1 green	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green London South GLH NHS GMS Phenotypes Aortic valve disease 2 614823 Tags
Green Green List (high evidence)	TGFB2	10 reviews 8 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Loeys-Dietz syndrome 4, 614816 Loeys-Dietz syndrome 4 (614816) Tags
Green Green List (high evidence)	TGFB3	10 reviews 6 green 1 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH South West GLH Phenotypes Loeys-Dietz syndrome 5, 615582 Arrhythmogenic right ventricular dysplasia 1, 107970 Tags
Green Green List (high evidence)	TGFBR1	8 reviews 7 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Loeys Dietz syndrome, type 2A, 608967 Loeys-Dietz syndrome Loeys Dietz syndrome, type 1A, 609192 Loeys Dietz syndrome, type 1A (609192) Tags
Green Green List (high evidence)	TGFBR2	9 reviews 7 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green London South GLH North West GLH South West GLH Phenotypes Loeys-Dietz syndrome Loeys Dietz syndrome, type 1B, 610168 Loeys Dietz syndrome, type 2 (610168) Loeys Dietz syndrome, type 2B, 610380 Tags
Amber Amber List (moderate evidence)	ARIH1	3 reviews 1 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber Literature Phenotypes Thoracic aortic aneurysm, MONDO:0005396 Tags
Amber Amber List (moderate evidence)	FOXE3	8 reviews 2 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber London South GLH South West GLH Phenotypes Aortic aneurysm, familial thoracic 11, (susceptibility to) 617349 Tags
Amber Amber List (moderate evidence)	LTBP3	3 reviews 2 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber NHS GMS Phenotypes Short stature dental anomalies aortopathy facial dysmorphism learning disability Dental anomalies and short stature, OMIM:601216 Tags
Amber Amber List (moderate evidence)	PMEPA1	2 reviews 1 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber Research Phenotypes thoracic aortic aneurysm, MONDO:0005396 tall stature dolichocephaly abnormal axial skeletal morphology pes planus Loeys-Dietz syndrome, MONDO:0018954 Tags Q4_23_NHS_review Q4_23_promote_green
Amber Amber List (moderate evidence)	SECISBP2	2 reviews 2 green	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Literature Phenotypes Thyroid hormone metabolism, abnormal, 1, OMIM:609698 thoracic aortic aneurysm Tags Q2_24_NHS_review Q2_24_promote_green
Amber Amber List (moderate evidence)	THSD4	3 reviews 1 green	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber Literature Phenotypes familial thoracic aortic aneurysm and aortic dissection, MONDO:0019625 Tags
Red Red List (low evidence)	ABCC6	5 reviews 4 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ACVR1	5 reviews 4 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ADAMTS2	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ALDH18A1	5 reviews 4 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ATP6V0A2	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ATP7A	5 reviews 3 red	X-LINKED: hemizygous mutation in males, biallelic mutations in females	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	B4GALT7	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	CHST14	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL11A1	5 reviews 4 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL11A2	5 reviews 4 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL1A1	9 reviews 2 green 3 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red London South GLH South West GLH Phenotypes Ehlers-Danlos syndrome, classic, 130000 Ehlers-Danlos syndrome, type VIIA, 130060 Tags
Red Red List (low evidence)	COL1A2	9 reviews 2 green 2 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red London South GLH South West GLH Phenotypes Ehlers-Danlos syndrome, cardiac valvular form Ehlers-Danlos syndrome, type VIIB Tags
Red Red List (low evidence)	COL2A1	5 reviews 4 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL4A1	6 reviews 5 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Phenotypes Angiopathy, hereditary, with nephropathy, aneurysms, and muscle, 611773 Hereditary Angiopathy with Nephropathy, Aneurysms, and Muscle Cramps Tags
Red Red List (low evidence)	COL9A1	5 reviews 4 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL9A2	5 reviews 4 red	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	COL9A3	5 reviews 4 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	EMILIN1	4 reviews 3 red	Not set	Sources Expert Review Red London South GLH Tags
Red Red List (low evidence)	FLCN	6 reviews 3 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red London South GLH NHS GMS South West GLH Phenotypes Birt-Hogg-Dube syndrome,135150 Pneumothorax, primary spontaneous, 173600 Tags
Red Red List (low evidence)	HEY2	2 reviews 1 red	BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal	Sources Expert Review Red Literature Phenotypes congenital heart defects, multiple type, MONDO:0000119 thoracic aortic aneurysm, MONDO:0005396 Tags
Red Red List (low evidence)	HNRNPK	6 reviews 4 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	KCNN1	5 reviews 4 red	Unknown	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	LTBP2	4 reviews 3 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Phenotypes Marfan syndrome Tags
Red Red List (low evidence)	MAT2A	4 reviews 2 red	Not set	Sources Expert Review Red London South GLH Tags
Red Red List (low evidence)	MED12	9 reviews 2 green 4 red	X-LINKED: hemizygous mutation in males, biallelic mutations in females	Sources Expert Review Red London South GLH NHS GMS South West GLH Phenotypes Lujan-Fryns syndrome, OMIM:309520 Marfan Syndrome, Thoracic Aortic Aneurysm & Dissection (TAAD), and Related Disorders Tags
Red Red List (low evidence)	MYLK2	4 reviews 3 red	Not set	Sources Expert Review Red London South GLH Tags
Red Red List (low evidence)	PKD1	4 reviews 3 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Phenotypes Connective Tissue Disorders Polycystic kidney disease, adult type I,173900 Tags
Red Red List (low evidence)	PKD2	4 reviews 3 red	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Red South West GLH Phenotypes Connective Tissue Disorders Polycystic kidney disease 2, 613095 Tags
Red Red List (low evidence)	SLC39A13	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	TNXB	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags
Red Red List (low evidence)	ZNF469	5 reviews 4 red	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red South West GLH Tags

Major version comments

2023-03-22 14:57 Catherine Snow (Genomics England) promoted panel to 3.0
The content of this panel has been updated in accordance with changes agreed with the NHS Genomic Medicine Service. The panel was promoted to the next major version (3.0) following this.

2022-11-30 15:20 Achchuthan Shanmugasundram (Genomics England Curator) promoted panel to 2.0
The content of this panel has been updated in accordance with changes agreed with the NHS Genomic Medicine Service. The panel was promoted to the next major version (2.0) following this.

2019-12-09 14:07 Ivone Leong (Genomics England Curator) promoted panel to 1.0
The content of this panel (version 0.60) was signed off under NHS Genomic Medicine Service governance on (09/12/2019). The panel was promoted to the next major version (version 1.0) as a result of this.

Thoracic aortic aneurysm or dissection (GMS) (Version 3.11)

27 reviewers

70 Entities

70 reviewed, 33 green

6 reviews

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8 reviews

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3 reviews

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8 reviews

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9 reviews

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8 reviews

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9 reviews

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9 reviews

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7 reviews

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8 reviews

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9 reviews

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