MEN1

menin 1
OMIM: 613733, Gene2Phenotype

17 panels

Panel Reviews Mode of inheritance Details
17 panels

Green MEN1 in Parathyroid Cancer

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.3

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • UKGTN
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Multiple endocrine neoplasia 1, 131100
  • Carcinoid tumor of lung
  • Parathyroid adenoma, somatic
  • Lipoma, somatic
  • Angiofibroma, somatic
  • Adrenal adenoma, somatic
  • Pituitary Cancer, Parathyroid and Hypercalcemia

Red MEN1 in Inherited non-medullary thyroid cancer

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.5

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Literature
Phenotypes
  • Familial Non-medullary Thyroid Cancer

Green MEN1 in Additional findings health related


Version 0.110

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert list
  • Expert Review Green
Phenotypes
  • Other cancer predisposition
  • Myltiple endocrine Neoplasia Type 1
  • Adult and child

Green MEN1 in Neuroendocrine cancer pertinent cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.0

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Neuroendocrine cancer

Red MEN1 in Familial Tumours Syndromes of the central & peripheral Nervous system

Level 3: Muscle and nerve
Level 2: Tumour syndromes
Version 1.9

review Not set
Sources
  • Expert Review Red
  • Emory Genetics Laboratory
Phenotypes
  • Brain, CNS, and PNS Cancer

Green MEN1 in Adult solid tumours for rare disease

Level 3: Tumour syndromes
Level 2: Tumour syndromes
Version 1.22

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert list
  • Expert Review Green
Phenotypes
  • Multiple Endocrine Neoplasia

Green MEN1 in Tumour predisposition - childhood onset

Level 3: Childhood Tumours
Level 2: Tumour syndromes
Version 2.16
Signed off v.2.5 on 4 Mar 2020

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
  • Expert list
  • Expert List
Phenotypes
  • Multiple Endocrine Neoplasia
  • Multiple endocrine neoplasia 1, 131100

Green MEN1 in Familial hyperparathyroidism


Version 2.5
Signed off v.2.3 on 3 Mar 2020

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Illumina TruGenome Clinical Sequencing Services
  • UKGTN
  • Emory Genetics Laboratory
Phenotypes
  • Multiple endocrine neoplasia 1 (131100)
  • Familial isolated hyperparathyroidism

Green MEN1 in Multiple endocrine tumours

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.9

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Eligibility statement prior genetic testing
  • Expert
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
  • UKGTN
  • Emory Genetics Laboratory
Phenotypes
  • Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication
  • Multiple Endocrine Neoplasia
  • Multiple endocrine neoplasia 1, 131100
  • Carcinoid tumor of lung
  • Parathyroid adenoma, somatic
  • Lipoma, somatic
  • Angiofibroma, somatic
  • Adrenal adenoma, somatic
  • MEN1-like spectrum
  • pituitary tumours
  • Endocrine Cancer

Green MEN1 in Inherited phaeochromocytoma and paraganglioma

Level 3: Breast and endocrine
Level 2: Tumour syndromes
Version 1.5

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • UKGTN
  • Emory Genetics Laboratory
  • Illumina TruGenome Clinical Sequencing Services
Phenotypes
  • Multiple Endocrine Neoplasia
  • Multiple endocrine neoplasia type 1 (MEN1)

Green MEN1 in Inherited phaeochromocytoma and paraganglioma excluding NF1


Version 1.5
Signed off v.1.4 on 11 Nov 2020

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Multiple endocrine neoplasia type 1 (MEN1)
  • Multiple Endocrine Neoplasia

Green MEN1 in Endocrine neoplasms


Version 1.4
Signed off v.1.3 on 15 Oct 2020

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Endocrine Cancer
  • pituitary tumours
  • Multiple Endocrine Neoplasia Type 1: MEN1 Gene Deletion/Duplication
  • Parathyroid adenoma, somatic
  • Multiple endocrine neoplasia 1, 131100
  • Carcinoid tumor of lung
  • Angiofibroma, somatic
  • Adrenal adenoma, somatic
  • Lipoma, somatic
  • MEN1-like spectrum
  • Multiple Endocrine Neoplasia

Green MEN1 in Childhood solid tumours cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.14

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Multiple Endocrine Neoplasia

Green MEN1 in Adult solid tumours cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 2.7
Signed off v.2.2 on 18 Feb 2020

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
  • Expert list
Phenotypes
  • Multiple Endocrine Neoplasia

Red MEN1 in Severe Paediatric Disorders


Version 1.43

review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Next Generation Children Project
  • Expert Review Red
  • Expert list
Phenotypes
  • {Chronic infections, due to MBL deficiency}, 614372

Green MEN1 in Additional findings health related - children


Version 0.17

Component of the following Super Panels:

  • Additional findings health related - adults
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Other cancer predisposition
    • Adult and child
    • Myltiple endocrine Neoplasia Type 1

    Green MEN1 in Additional findings health related - CNV analysis children


    Version 0.12

    Component of the following Super Panels:

  • Additional findings health related - CNV analysis adults
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert list
    • Expert Review Green
    Phenotypes
    • Myltiple endocrine Neoplasia Type 1
    • Other cancer predisposition
    • Adult and child