1. Genes and Genomic Entities
  2. NADK2

NADK2

NAD kinase 2, mitochondrial
OMIM: 615787, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green NADK2 in Likely inborn error of metabolism


Level 2: Metabolic
Version 9.7
Latest signed off version: v9.0 (6 May 2026)

Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Green
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Green NADK2 in Possible mitochondrial disorder - nuclear genes


    Level 2: Mitochondrial
    Version 5.4
    Latest signed off version: v5.0 (6 May 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Amber NADK2 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 7.12
    Latest signed off version: v7.0 (6 May 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Red NADK2 in DDG2P


    Version 7.1
    Latest signed off version: v7.0 (6 May 2026)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Red
    Phenotypes
    • Dienoyl-CoA reductase deficiency with hyperlysinemia
    Red NADK2 in Intellectual disability


    Level 2: Developmental disorders
    Version 10.18
    Latest signed off version: v10.0 (6 May 2026)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Literature
    • Literature
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Green NADK2 in Mitochondrial disorders


    Level 2: Mitochondrial
    Version 10.4
    Latest signed off version: v10.0 (6 May 2026)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Tags
    • treatable