1. Genes and Genomic Entities
  2. NADK2

NADK2

NAD kinase 2, mitochondrial
OMIM: 615787, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green NADK2 in Likely inborn error of metabolism


Level 2: Metabolic
Version 9.32
Latest signed off version: v9.29 (12 Aug 2026)

Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Green
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Green NADK2 in Possible mitochondrial disorder, nuclear genes


    Level 2: Mitochondrial
    Version 5.25
    Latest signed off version: v5.17 (12 Aug 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Amber NADK2 in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 8.5
    Latest signed off version: v8.0 (12 Aug 2026)

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Red NADK2 in DDG2P


    Version 8.2
    Latest signed off version: v8.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • DD-Gene2Phenotype
    • Expert Review Red
    Phenotypes
    • Dienoyl-CoA reductase deficiency with hyperlysinemia
    Red NADK2 in Intellectual disability


    Level 2: Developmental disorders
    Version 11.28
    Latest signed off version: v11.0 (12 Aug 2026)

    Component of the following Super Panels:

  • Hypotonic infant
  • Leukodystrophy, childhood onset
  • Paediatric disorders

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Literature
    • Literature
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Green NADK2 in Mitochondrial disorders


    Level 2: Mitochondrial
    Version 10.25
    Latest signed off version: v10.18 (12 Aug 2026)

    Component of the following Super Panels:

  • Leukodystrophy, childhood onset

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert
    Phenotypes
    • 2,4-dienoyl-CoA reductase deficiency, OMIM:616034
    Tags
    • treatable