PROC

protein C, inactivator of coagulation factors Va and VIIIa
OMIM: 612283, Gene2Phenotype

3 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 3 panels
Green PROC in Inherited bleeding disorders Level 3: Haemostasis disorders Level 2: Haematological and immunological disorders Version 1.182	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Eligibility statement prior genetic testing UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Expert Review Green BRIDGE Study Tier 1 Gene Phenotypes Protein C deficiency Protein C Deficiency Thrombophilia due to protein C deficiency, autosomal dominant 176860 Thrombophilia due to protein C deficiency, autosomal recessive 612304 Thrombophilia Due To Protein C Deficiency, Autosomal Dominant Thrombophilia Due To Protein C Deficiency, Autosomal Recessive
Green PROC in Thrombophilia with a likely monogenic cause Level 2: Haematology Version 2.10 Latest signed off version: v2.2 (22 Mar 2023)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes Thrombophilia due to protein C deficiency, autosomal recessive, OMIM:612304 Thrombophilia due to protein C deficiency, autosomal dominant, OMIM:176860
Amber PROC in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.181 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Phenotypes Thrombophilia 3 due to protein C deficiency, autosomal recessive