PROC

protein C, inactivator of coagulation factors Va and VIIIa
OMIM: 612283, Gene2Phenotype

3 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 3 panels
Green PROC in Inherited bleeding disorders Level 3: Haemostasis disorders Level 2: Haematological and immunological disorders Version 1.178	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Eligibility statement prior genetic testing UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Expert Review Green BRIDGE Study Tier 1 Gene Phenotypes Protein C deficiency Protein C Deficiency Thrombophilia due to protein C deficiency, autosomal dominant 176860 Thrombophilia due to protein C deficiency, autosomal recessive 612304 Thrombophilia Due To Protein C Deficiency, Autosomal Dominant Thrombophilia Due To Protein C Deficiency, Autosomal Recessive
Green PROC in Thrombophilia with a likely monogenic cause Version 2.5 Latest signed off version: v2.2 (22 Mar 2023)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH London South GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes Thrombophilia due to protein C deficiency, autosomal recessive, OMIM:612304 Thrombophilia due to protein C deficiency, autosomal dominant, OMIM:176860
Green PROC in Severe Paediatric Disorders Version 1.184	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Next Generation Children Project Expert Review Green Expert list Phenotypes Thrombophilia due to protein C deficiency, autosomal recessive, 612304 Thrombophilia due to protein C deficiency, autosomal dominant, 176860