1. Genes and Genomic Entities
  2. SCN10A

SCN10A

sodium voltage-gated channel alpha subunit 10
OMIM: 604427, Gene2Phenotype

7 panels

Panel Reviews Mode of inheritance Details
7 panels
Red SCN10A in Short QT syndrome


Level 2: Cardiology
Version 3.16
Latest signed off version: v3.14 (30 Apr 2025)

Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • North West GLH
    • Expert Review Red
    • Brugada syndrome (Version 1.7)
    • Literature
    Phenotypes
    • J wave syndrome
    • short QT
    • Episodic pain syndrome, familial, 2 (615551)
    • sudden death
    Red SCN10A in Brugada syndrome and cardiac sodium channel disease


    Level 2: Cardiology
    Version 3.14
    Latest signed off version: v3.12 (30 Apr 2025)

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden unexplained death or survivors of a cardiac event
  • Unexplained death in infancy and sudden unexplained death in childhood

    		•  review Unknown
    Sources
    • Expert Review Red
    • South West GLH
    • London South GLH
    • North West GLH
    • Oxford Medical Genetics Laboratory
    Phenotypes
    • Brugada syndrome, MONDO:0015263
    Green SCN10A in Pain syndromes

    Level 3: Channelopathies
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.12

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • BRIDGE Study Tier 1 Gene
    Phenotypes
    • Familial episodic pain syndrome-2
    • Episodic pain syndrome, familial, 2, 615551
    • Painful small fibre neuropathy
    • SFN
    • Small fibre neuropathy
    Red SCN10A in Paroxysmal central nervous system disorders


    Level 2: Neurology
    Version 4.2
    Latest signed off version: v4.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • NHS GMS
    • London North GLH
    • Wessex and West Midlands GLH
    Phenotypes
    • Painful small fibre neuropathy
    • SFN
    • Small fibre neuropathy
    • Familial episodic pain syndrome-2
    • Episodic pain syndrome, familial, 2, 615551
    Green SCN10A in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.506

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • London North GLH
    Phenotypes
    • Episodic pain syndrome, familial, 2, 615551
    Green SCN10A in Hereditary neuropathy or pain disorder


    Level 2: Neurology
    Version 7.36
    Latest signed off version: v7.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • London North GLH
    • NHS GMS
    • NHS GMS
    • London North GLH
    Phenotypes
    • Episodic pain syndrome, familial, 2, 615551
    Red SCN10A in Paediatric pseudo-obstruction syndrome


    Level 2: Gastrohepatology
    Version 2.5
    Latest signed off version: v2.0 (30 Apr 2025)

    		review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert list
    Phenotypes
    • Colon sensory neurons activation