SCN10A

sodium voltage-gated channel alpha subunit 10
OMIM: 604427, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels

Red SCN10A in Short QT syndrome


Version 2.7
Signed off v.2.4 on 20 Aug 2020

Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden cardiac death
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • North West GLH
    • Expert Review Red
    • Brugada syndrome (Version 1.7)
    • Literature
    Phenotypes
    • J wave syndrome
    • short QT
    • Episodic pain syndrome, familial, 2 (615551)
    • sudden death

    Red SCN10A in Brugada syndrome

    Level 3: Cardiac arrhythmia
    Level 2: Cardiovascular disorders
    Version 2.5
    Signed off v.2.4 on 20 Aug 2020

    Component of the following Super Panels:

  • Cardiac arrhythmias
  • Sudden cardiac death
  • review Unknown
    Sources
    • Expert Review Red
    • South West GLH
    • London South GLH
    • North West GLH
    • Oxford Medical Genetics Laboratory
    Phenotypes
    • Episodic pain syndrome, familial, 2 (615551)

    Green SCN10A in Pain syndromes

    Level 3: Channelopathies
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.9

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • BRIDGE Study Tier 1 Gene
    Phenotypes
    • Familial episodic pain syndrome-2
    • Episodic pain syndrome, familial, 2, 615551
    • Painful small fibre neuropathy
    • SFN
    • Small fibre neuropathy

    Red SCN10A in Paroxysmal central nervous system disorders


    Version 1.10
    Signed off v.1.2 on 27 Feb 2020

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Red
    • NHS GMS
    • London North GLH
    • Wessex and West Midlands GLH
    Phenotypes
    • Painful small fibre neuropathy
    • SFN
    • Small fibre neuropathy
    • Familial episodic pain syndrome-2
    • Episodic pain syndrome, familial, 2, 615551

    Green SCN10A in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.383

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • NHS GMS
    • London North GLH
    Phenotypes
    • Episodic pain syndrome, familial, 2, 615551

    Green SCN10A in Hereditary neuropathy NOT PMP22 copy number


    Version 1.21
    Signed off v.1.2 on 27 Feb 2020

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • London North GLH
    • NHS GMS
    • NHS GMS
    • London North GLH
    Phenotypes
    • Episodic pain syndrome, familial, 2, 615551